Ravuconazole
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Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent
triazole A triazole is a heterocyclic compound featuring a five-membered ring of two carbon atoms and three nitrogen atoms with molecular formula C2H3N3. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within t ...
antifungal An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as crypto ...
, the development of which was discontinued in 2007. The drug has shown to have a similar spectrum of activity to
voriconazole Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by '' ...
, with an increased half-life. However, ravuconazole has limited activity against species of ''
Fusarium ''Fusarium'' is a large genus of filamentous fungi, part of a group often referred to as hyphomycetes, widely distributed in soil and associated with plants. Most species are harmless saprobes, and are relatively abundant members of the soil mi ...
'', ''
Scedosporium ''Scedosporium'' is a genus (biology), genus of fungi in the family Microascaceae. The genus shed the alternative name ''Pseudallescheria'' as the "One Fungus, One Name" principle overtook the previous dual naming system, which had a distinct na ...
'', and ''
Zygomycetes Zygomycota, or zygote fungi, is a former division or phylum of the kingdom Fungi. The members are now part of two phyla: the Mucoromycota and Zoopagomycota. Approximately 1060 species are known. They are mostly terrestrial in habitat, living in ...
''.


See also

*
Albaconazole Albaconazole (development code UR-9825) is an experimental triazole antifungal. It has potential broad-spectrum activity. The drug blocks a number of CYP450 liver enzymes. It has also been studied as an antiprotozoal Antiprotozoal agents ( ATC ...
*
Fosravuconazole Fosravuconazole (trade name Nailin) is a triazole antifungal agent. In Japan, it is approved for the treatment of onychomycosis, a fungal infection of the nail. It is a prodrug that is converted into ravuconazole. The Drugs for Neglected Dise ...
, a prodrug of ravuconazole *
Isavuconazole Isavuconazonium sulfate, sold under the brand name Cresemba, is a systemic antifungal medication of the triazole class which is used to treat invasive aspergillosis and mucormycosis. The most common side effects include abnormal liver tests, ...


References

27-Hydroxylase inhibitors Lanosterol 14α-demethylase inhibitors Nitriles Fluoroarenes Phenylethanolamines Tertiary alcohols Thiazoles Triazole antifungals Abandoned drugs {{antiinfective-drug-stub