Rap GTP-binding protein also known as Ras-related proteins or simply RAP is a type of
small GTPase, similar in structure to
Ras
Ras or RAS may refer to:
Arts and media
* RAS Records Real Authentic Sound, a reggae record label
* Rundfunk Anstalt Südtirol, a south Tyrolese public broadcasting service
* Rás 1, an Icelandic radio station
* Rás 2, an Icelandic radio sta ...
.
These proteins share approximately 50% amino acid identity with the classical
RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid:
glutamine
Glutamine (symbol Gln or Q) is an α-amino acid that is used in the biosynthesis of proteins. Its side chain is similar to that of glutamic acid, except the carboxylic acid group is replaced by an amide. It is classified as a charge-neutral ...
in RAS is replaced by
threonine
Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH form under biological conditions), a carboxyl group (which is in the deprotonated −COOâ ...
in RAP proteins. RAP counteracts the
mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner.
Family members
Human genes that encode Ras-related proteins include:
*
RAP1A,
RAP1B
*
RAP2A
Ras-related protein Rap-2a is a protein that in humans is encoded by the ''RAP2A'' gene. RAP2A is a member of the Ras-related protein family.
Interactions
RAP2A has been shown to interact with RUNDC3A, RASSF5 and RALGDS
Ral guanine nucleoti ...
,
RAP2B,
RAP1C
*
RAB5C
References
External links
*
EC 3.6.5
Peripheral membrane proteins
{{membrane-protein-stub