RUB A535 (also known as Antiphlogistine) is a

rubefacient A rubefacient is a substance for topical application that produces redness of the skin, e.g. by causing dilation of the capillaries and an increase in blood circulation. They have sometimes been used to relieve acute or chronic pain, but there is l ...

introduced in 1919 and manufactured by

Church & Dwight Church & Dwight is an American consumer goods company focusing on personal care, household products, and specialty products. The company was founded in 1846 and is headquartered in Ewing, New Jersey. It is the parent company of well-known brands ...

Montreal, Quebec Montreal ( ; officially Montréal, ) is the second-most populous city in Canada and most populous city in the Canadian province of Quebec. Founded in 1642 as '' Ville-Marie'', or "City of Mary", it is named after Mount Royal, the triple-pe ...

, Canada.

While little known outside of Canada, it is used there for the treatment of tough

muscle pain Myalgia (also called muscle pain and muscle ache in layman's terms) is the medical term for muscle pain. Myalgia is a symptom of many diseases. The most common cause of acute myalgia is the overuse of a muscle or group of muscles; another like ...

, arthritic pains,

rheumatic pains Rheumatism or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. Rheumatism does not designate any specific disorder, but covers at least 200 different conditions, including a ...

, bursitis,

lumbago Low back pain (LBP) or wiktionary:lumbago#Etymology, lumbago is a common musculoskeletal disorders, disorder involving the muscles, nerves, and bones of the back, in between the lower edge of the ribs and the lower fold of the buttocks. Pain can ...

, etc. Church and Dwight say on their website that nearly all the research, development and production of RUB A535 is carried out in Canada. Patients who are allergic to

salicylates Salicylic acid is an organic compound with the formula HOC6H4CO2H. A colorless, bitter-tasting solid, it is a precursor to and a metabolite of aspirin (acetylsalicylic acid). It is a plant hormone, and has been listed by the EPA Toxic Substa ...

(ASA based drugs, such as

aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ...

), or who are taking anticoagulant medications should avoid the use of the product. It is also recommended to not use it more than 3–4 times a day.

Ingredients

The active ingredients in RUB A535 are camphor,

eucalyptus oil Eucalyptus oil is the generic name for distilled oil from the leaf of ''Eucalyptus'', a genus of the plant family Myrtaceae native to Australia and cultivated worldwide. Eucalyptus oil has a history of wide application, as a pharmaceutical, anti ...

, menthol, and

methyl salicylate Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic compound with the formula C8H8O3. It is the methyl ester of salicylic acid. It is a colorless, viscous liquid with a sweet, fruity odor reminiscent of root beer, but often a ...

. Some formulations also contain

capsaicin Capsaicin (8-methyl-''N''-vanillyl-6-nonenamide) ( or ) is an active component of chili peppers, which are plants belonging to the genus ''Capsicum''. It is a chemical irritant for mammals, including humans, and produces a sensation of burnin ...

and

triethanolamine Triethanolamine, or TEA is a viscous organic compound that is both a tertiary amine and a triol. A triol is a molecule with three alcohol groups. Approximately 150,000 tonnes were produced in 1999. It is a colourless compound although samples m ...

Varieties

Currently, RUB A535 has been released in a variety of products: * Originally, it was produced in a particular white cream, carrying a rather offensive medical odor. * Recently, the name was also given to a line of dual action back patches that change temperature (known as Hot-Cold patches). * An improved cream was also developed, claiming to be odorless, differing from their normal cream, which carries the same smell as most topical analgesics. * As of 2008 the "Ultra Heat" sport stick was released and shipped to many provinces including Manitoba. The package looks like an orange deodorant stick, that is a little taller than usual. Says sport along the left side. Comes in a 100g stick, is a spearmint smelling cream, and gets dispensed by turning the dial at the bottom like deodorant, and it is forced through three slits at the top, under a cap. * There is also a cold A535 named "Ice"

References in other disciplines

Historically, the then local distributor was involved in a notable case in the High Court of Australia, about State income tax, ''Denver Chemical Manufacturing Company v The Commissioner of Taxation (New South Wales)'
(1949) 79 CLR 296
It simply involved a difference of views about how to disclose income on a tax return, but is th
leading authority
in its area.

External links

Official Website

References

{{DEFAULTSORT:Rub A535 Analgesics Ointments Church & Dwight brands Goods manufactured in Canada

Ingredients

Varieties

See also

References in other disciplines

External links

References