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NM_000635
NM_134433

NM_009056
NM_027787

RefSeq (protein)

NP_000626
NP_602309

NP_033082
NP_082063

Location (UCSC) Chr 19: 5.99 – 6.2 Mb Chr 17: 56.78 – 56.83 Mb PubMed search [3] [4] Wikidata
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DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.[5][6]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087903 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024206 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics. 13 (4): 1307–10. doi:10.1016/0888-7543(92)90052-T. PMID 1505960. 
  6. ^ a b "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)". 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.