{{Drugbox
, IUPAC_name = ''N''-
{(6''R'',9''S'',10''R'',13''S'',15a''S'',18''R'',22''S'',24a''S'')-18-
{
3''S'')-1-azabicyclo[2.2.2ct-3-ylthio">.2.2.html" ;"title="3''S'')-1-azabicyclo[2.2.2">3''S'')-1-azabicyclo[2.2.2ct-3-ylthioethyl}-22-[4-(dimethylamino)benzyl]-
6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12''H''-
pyrido[2,1-''f'']pyrrolo-[2,1-''l''][1,4,7,10,13,16] oxapentaazacyclononadecin-9-yl}-3-
hydroxypyridine-2-carboxamide
, image = Quinupristin.png
, CAS_number = 120138-50-3
, UNII_Ref = {{fdacite, correct, FDA
, UNII = 23OW28RS7P
, ATC_prefix =
, ATC_suffix =
, PubChem = 5388937
, DrugBank =
, ChEMBL = 1200649
, ChemSpiderID = 4470884
, smiles = CC
@@HC(=O)N2CCC
@HC(=O)N(
@HC(=O)N3C
@HC(=O)C
@HC(=O)N
@HC(=O)O
@@H @@HC(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CS
@@HCN7CCC6CC7)CC8=CC=C(C=C8)N(C)C)C
, StdInChI = 1S/C53H67N9O10S/c1-6-37-50(68)61-23-11-14-38(61)51(69)59(5)40(26-32-16-18-36(19-17-32)58(3)4)52(70)62-28-35(30-73-43-29-60-24-20-33(43)21-25-60)42(64)27-39(62)47(65)57-45(34-12-8-7-9-13-34)53(71)72-31(2)44(48(66)55-37)56-49(67)46-41(63)15-10-22-54-46/h7-10,12-13,15-19,22,31,33,35,37-40,43-45,63H,6,11,14,20-21,23-30H2,1-5H3,(H,55,66)(H,56,67)(H,57,65)/t31-,35+,37-,38+,39+,40+,43-,44+,45+/m1/s1
, StdInChIKey = WTHRRGMBUAHGNI-LCYNINFDSA-N
, C=53, H=67, N=9, O=10, S=1
, bioavailability =
, protein_bound =
, metabolism =
, elimination_half-life = 3.1 hours
, excretion =
, pregnancy_AU =
, pregnancy_US =
, pregnancy_category=
, legal_AU =
, legal_CA =
, legal_UK =
, legal_US =
, legal_status =
, routes_of_administration =
Quinupristin is a
streptogramin B Streptogramin B is a subgroup of the streptogramin antibiotics family. These natural products are cyclic hexa- or hepta depsipeptides produced by various members of the genus of bacteria '' Streptomyces''. Many of the members of the streptogramins ...
antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ...
, used in combination with dalfopristin under the trade name Synercid. It has activity against Gram-positive bacteria, Gram-positive and atypical bacteria but not Gram-negative bacteria. It inhibits bacterial protein synthesis. The combination of quinupristin and dalfopristin is not active against ''Enterococcus faecalis'' and needs to be given in combination with other antibacterials for mixed infections that involve Gram-negative organisms.
Antibiotics