Quadrosilan (, ) (brand name Cisobitan; former developmental code name KABI-1774) is a
synthetic nonsteroidal estrogen
A nonsteroidal estrogen is an estrogen with a nonsteroidal chemical structure. The most well-known example is the stilbestrol estrogen diethylstilbestrol (DES). Although nonsteroidal estrogens formerly had an important place in medicine, they ha ...
that was developed in the 1970s and that is or has been used as an
antigonadotropic agent in the treatment of
prostate cancer.
It is an
organosilicon compound, and is also known as 2,6-cisdiphenylhexamethylcyclotetrasiloxane.
Quadrosilan has
estrogen
Estrogen or oestrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal ac ...
ic activity equivalent to that of
estradiol
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is responsible for the development o ...
,
and can produce
feminization and
gynecomastia
Gynecomastia (also spelled gynaecomastia) is the abnormal non-cancerous enlargement of one or both breasts in males due to the growth of breast tissue as a result of a hormone imbalance between estrogens and androgens. Updated by Brent Wisse ( ...
as
side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequence ...
s in male patients.
See also
*
Paroxypropione
Paroxypropione, also known as paraoxypropiophenone, is a synthetic nonsteroidal estrogen which has been used medically as an antigonadotropin in Spain and Italy but appears to no longer be marketed. It was first synthesized in 1902. The antigona ...
*
Metallibure
Metallibure () (brand names Aimax, Suisynchron, Turisynchron; former developmental code names ICI-33828, AY-61122, NSC-69536), also known as methallibure (, ) or methallibur (German), is a medication which was introduced in 1973 and has been used ...
References
{{Estrogen receptor modulators
Abandoned drugs
Antigonadotropins
Hormonal antineoplastic drugs
Siloxanes
Synthetic estrogens