In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a prostaglandin-E
2 9-reductase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP
+ (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H
+
Thus, the two
substrates of this enzyme are
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate and
NADP+, whereas its 3
products are
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate,
NADPH
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NAD ...
, and
H+.
This enzyme belongs to the family of
oxidoreductases, specifically those acting on the CH-OH group of donor with NAD
+ or NADP
+ as acceptor. The
systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP
+ 9-oxidoreductase. Other names in common use include PGE
2-9-OR, reductase, 15-hydroxy-9-oxoprostaglandin, 9-keto-prostaglandin E
2 reductase, 9-ketoprostaglandin reductase, PGE-9-ketoreductase, PGE
2 9-oxoreductase, PGE
2 reductase-9-ketoreductase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, and prostaglandin E
2 reductase-9-oxoreductase. This enzyme participates in
arachidonic acid metabolism.
Structural studies
As of late 2007, 3
structures have been solved for this class of enzymes, with
PDB accession codes , , and .
References
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EC 1.1.1
NADPH-dependent enzymes
Enzymes of known structure
{{1.1.1-enzyme-stub