A prospective cohort study is a

longitudinal Longitudinal is a geometric term of location which may refer to: * Longitude ** Line of longitude, also called a meridian * Longitudinal engine, an internal combustion engine in which the crankshaft is oriented along the long axis of the vehicl ...

cohort study A cohort study is a particular form of longitudinal study that samples a cohort (a group of people who share a defining characteristic, typically those who experienced a common event in a selected period, such as birth or graduation), performing ...

that follows over time a group of similar individuals (

cohort Cohort or cohortes may refer to: * Cohort (educational group), a group of students working together through the same academic curriculum * Cohort (floating point), a set of different encodings of the same numerical value * Cohort (military unit ...

s) who differ with respect to certain factors under study, to determine how these factors affect rates of a certain outcome. For example, one might follow a cohort of middle-aged truck drivers who vary in terms of smoking habits, to test the hypothesis that the 20-year incidence rate of lung cancer will be highest among heavy smokers, followed by moderate smokers, and then nonsmokers. The prospective study is important for research on the etiology of diseases and disorders. The distinguishing feature of a prospective cohort study is that at the time that the investigators begin enrolling subjects and collecting baseline exposure information, none of the subjects have developed any of the outcomes of interest. After baseline information is collected, subjects in a prospective cohort study are then followed "longitudinally," i.e. over a period of time, usually for years, to determine if and when they become diseased and whether their exposure status changes outcomes. In this way, investigators can eventually use the data to answer many questions about the associations between "risk factors" and disease outcomes. For example, one could identify smokers and non-smokers at baseline and compare their subsequent incidence of developing heart disease. Alternatively, one could group subjects based on their body mass index (BMI) and compare their risk of developing heart disease or cancer. Prospective cohort studies are typically ranked higher in the hierarchy of evidence than retrospective cohort studies and can be more expensive than a

case–control study A case–control study (also known as case–referent study) is a type of observational study in which two existing groups differing in outcome are identified and compared on the basis of some supposed causal attribute. Case–control studies ar ...

. One of the advantages of prospective cohort studies is they can help determine risk factors for being infected with a new disease because they are a longitudinal observation over time, and the collection of results is at regular time intervals, so recall error is minimized.

Reporting

The Strengthening the Reporting of OBservational studies in Epidemiology ( STROBE) recommends that authors refrain from calling a study ‘prospective’ or ‘ retrospective’ due to these terms having contradictory and overlapping definitions. STROBE also recommends that whenever authors use these words, they specify which definition they use, including a detailed description of how and when data collection took place.

Examples

* Caerphilly Heart Disease Study, UK.
Canadian Longitudinal Study on Aging / Étude longitudinale canadienne sur le vieillissement (CLSA-ÉLCV)

The CARTaGENE cohort / Quebec's largest prospective study
Quebec, Canada
Cebu Longitudinal Health and Nutrition Survey
the Philippines *

Framingham Heart Study The Framingham Heart Study is a long-term, ongoing cardiovascular cohort study of residents of the city of Framingham, Massachusetts. The study began in 1948 with 5,209 adult subjects from Framingham, and is now on its third generation of partic ...

, USA. * Million Women Study, UK. * Rotterdam Study, Netherlands.
Tsimane’ Amazonian Panel Study
Bolivia
The UK biobank
UK

References

{{DEFAULTSORT:Prospective Cohort Study Cohort study methods

Reporting

Examples

See also

References