Promestriene () (brand names Colpotrofin, Colpotrophine, Delipoderm), also known as estradiol 3-propyl 17β-methyl diether, is a synthetic compound, synthetic estrogen (medication), estrogen which is used topical medication, topically in a 1% cream (pharmaceutical), cream formulation for the treatment of vaginal atrophy in women.
It is the 3-propyl group, propyl and 17β-methyl group, methyl ether, diether of estradiol (medication), estradiol and does not appear to convert into estradiol in the body.
Promestriene is minimally absorption (pharmacokinetics), absorbed and appears to have negligible systemic estrogenic effect.
The drug has been described as a growth factor, tropic agent and antiseborrheic.
It has not been found to be effective in the treatment of androgenic alopecia, pattern hair loss or other conditions of cutaneous androgenization.
Promestriene was first introduced in France in 1974 and has been marketed in 34 countries worldwide.
It has been used in millions of women.
See also
* List of estrogen esters#Ethers of steroidal estrogens, List of estrogen esters § Ethers of steroidal estrogens
References
Diols
Estranes
Estrogen ethers
Synthetic estrogens
{{Genito-urinary-drug-stub