The Info List - Pneumonic Plague

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PNEUMONIC PLAGUE is a severe lung infection caused by the bacterium _ Yersinia pestis _. Symptoms include fever , headache, shortness of breath , chest pain , and cough. They typically start about three to seven days after exposure. It is one of three forms of plague , the other two being septicemic plague and bubonic plague .

The pneumonic form may occur following an initial bubonic or septicemic plague infection. It may also result from breathing in airborne droplets from another person or cat infected with pneumonic plague. The difference between the forms of plague is the location of infection; in pneumonic plague the infection is in the lungs, in bubonic plague the lymph nodes , and in septicemic plague within the blood. Diagnosis is by testing the blood, sputum, or fluid from a lymph node.

While vaccines are being worked on, in most countries they are not yet commercially available. Prevention is generally by avoiding contact with rodents . It is recommended that those infected be isolated from others. Treatment of pneumonic plague is with antibiotics .

Plague is present among rodents in Africa, the Americas, and Asia. Pneumonic plague is more serious and less common than bubonic plague. The total repeated number of all types of plague in 2013 was 783. Untreated pneumonic plague has a mortality of nearly 100%. Some hypothesis that the pneumonic version of the plague was mainly responsible for the Black Death that resulted in approximately 50 million deaths in the 1300s.


* 1 Signs and symptoms * 2 Spread * 3 Treatment

* 4 Epidemiology

* 4.1 India * 4.2 China * 4.3 Peru * 4.4 Madagascar * 4.5 United States

* 5 References * 6 External links


The most apparent symptom of pneumonic plague is coughing, often with hemoptysis (coughing up blood). With pneumonic plague, the first signs of illness are fever, headache, weakness and rapidly developing pneumonia with shortness of breath, chest pain, cough and sometimes bloody or watery sputum .

The pneumonia progresses for two to four days and may cause respiratory failure and shock . Patients will die without early treatment, some within 36 hours.

Initial pneumonic plague symptoms can often include the following:

* Fever * Weakness * Headaches * Nausea

Rapidly developing pneumonia with:

* Shortness of breath * Chest pain * Cough * Bloody or watery sputum (saliva and discharge from respiratory passages ).


Pneumonic plague can be caused in two ways: primary, which results from the inhalation of aerosolised plague bacteria , or secondary, when septicaemic plague spreads into lung tissue from the bloodstream. Pneumonic plague is _not_ exclusively vector-borne like bubonic plague; instead it can be spread from person to person. There have been cases of pneumonic plague resulting from the dissection or handling of contaminated animal tissue. This is one type of the plague formerly known as the Black Death .


Pneumonic plague is a very aggressive infection requiring early treatment. Antibiotics must be given within 24 hours of first symptoms to reduce the risk of death. Streptomycin , gentamicin , tetracyclines and chloramphenicol are all effective against pneumonic plague.

Antibiotic treatment for seven days will protect people who have had direct, close contact with infected patients. Wearing a close-fitting surgical mask also protects against infection.

The mortality rate from untreated pneumonic plague approaches 100%.


Since 2002, the World Health Organization (WHO) has reported seven plague outbreaks, though some may go unreported because they often happen in remote areas. Between 1998 and 2009, nearly 24,000 cases have been reported, including about 2,000 deaths, in Africa , Asia , the Americas , and Eastern Europe . Ninety-eight percent of the world's cases occur in Africa.


In September 1994, India experienced an outbreak of plague that killed 50 and caused travel to New Delhi by air to be suspended until the outbreak was brought under control. The outbreak was feared to be much worse because the plague superficially resembles other common diseases such as influenza and bronchitis; over 200 people that had been quarantined were released when they did not test positive for the plague. All but two of the deaths occurred around the city of Surat .


The People\'s Republic of China has eradicated the pneumonic plague from most parts of the country, but still reports occasional cases in remote Western areas where the disease is carried by rats and the marmots that live across the Himalayan plateau . Outbreaks can be caused when a person eats an infected marmot or comes into contact with fleas carried by rats. A 2006 WHO report from an international meeting on plague cited a Chinese government disease expert as saying that most cases of the plague in China's northwest occur when hunters are contaminated while skinning infected animals.

The expert said at the time that due to the region's remoteness, the disease killed more than half the infected people. The report also said that since the 1990s, there was a rise in plague cases in humans—from fewer than 10 in the 1980s to nearly 100 cases in 1996 and 254 in 2000. Official statistics posted on the Chinese Health Ministry 's Web site showed no cases of plague in 2007 and 2008. In September 2008, two people in east Tibet died of pneumonic plague.

A recent outbreak of the disease in China began in August 2009 in Ziketan Town located in Qinghai Province . The town was sealed off and several people died as a result of the disease. According to spokesperson Vivian Tan of the WHO office in Beijing , "In cases like this , we encourage the authorities to identify cases, to investigate any suspicious symptoms among close contacts, and to treat confirmed cases as soon as possible. So far, they have done exactly that. There have been sporadic cases reported around the country in the last few years so the authorities do have the experience to deal with this."

In September 2010, five cases of pneumonic plague were reported in Tibet.

In July 17, 2014, Chinese media reported one case found in Gansu.


In August 2010, Peru's health minister Oscar Ugarte announced that an outbreak of plague had killed a 14-year-old boy and had infected at least 31 people in a northern coastal province. The boy died of bubonic plague on 26 July 2010. Ugarte stated that authorities were screening sugar and fish meal exports from Ascope Province , located about 325 miles (520 km) northwest of Lima , not far from popular Chicama beach . Most of the infections in Peru were bubonic plague, with four cases of pneumonic plague.

The first recorded plague outbreak in Peru was in 1903. The last, in 1994, killed 35 people.


An outbreak of plague in November 2013, occurred in the African island nation of Madagascar . As of 16 December, at least 89 people were infected, with 39 deaths with at least two cases involving pneumonic plague. However, as many as 90% of cases were later reported to have involved pneumonic plague. The WHO and Institut Pasteur were both involved in administering antibiotic compounds and attempting to stop the spread of the disease.


On November 2, 2007, wildlife biologist Eric York died of pneumonic plague in Grand Canyon National Park . York was exposed to the bacteria while conducting a necropsy on a mountain lion carcass.

On July 10, 2014, in an online news story article, by Keith Coffman of Reuters , featured on the MSN U.S. News website, it was stated that a Colorado man, whose condition the report said was not known, had been diagnosed with the pneumonic plague. The man was found to have the disease after the family dog died unexpectedly and a necropsy conducted on it revealed it had died from the disease, which is spread when fleas which have been hosted by rodents (mostly prairie dogs) spread to another nearby host once the original one dies. The plague is found in the western U.S., according to the CDC.

As of July 18, 2014, three more cases were reported in Colorado. However, the outbreak appears to be over, according to state officials. The outbreak was caused by a pit bull .


* ^ _A_ _B_ _C_ _D_ _E_ _F_ _G_ _H_ _I_ "FAQ Plague". _www.cdc.gov_. Retrieved 13 March 2017. * ^ _A_ _B_ _C_ _D_ _E_ _F_ "Plague". _World Health Organization_. September 2016. Retrieved 14 March 2017. * ^ _A_ _B_ _C_ _D_ _E_ _F_ _G_ _H_ _I_ _J_ "Plague". _www.who.int_. Retrieved 14 March 2017. * ^ McCoy, Terrence (31 March 2014). "Everything you know about the Black Death is wrong". _Washington Post_. The Washington Post. Retrieved 14 March 2017. * ^ _A_ _B_ _C_ Facts about Pneumonic Plague (Center for Disease Control, 2004) * ^ Benedictow, Ole Jørgen (2004). _The Black Death, 1346–1353: The Complete History_. Boydell & Brewer. pp. 27–28. ISBN 0-85115-943-5 . * ^ Plague. (Iowa State University, 2004) * ^ Plague Fears Cancel Flights. The Daily Gleaner, October 1, 1994. * ^ Plague Fears Beginning to Recede. The Daily Gleaner, October 2, 1994. * ^ _A_ _B_ "China disinfects town where plague killed 3rd man". Associated Press. 2009-08-04. * ^ Macartney, Jane (August 3, 2009). Entire town in quarantine after two die from pneumonic plague in China. _ The Times _ (London). * ^ Two deaths from rare, deadly plague in Tibet * ^ "4th plague patient near death in NW China province". Xinhua. 2009-08-05. * ^ Alert over China plague outbreak. Al Jazeera . August 3, 2009. * ^ Dawa, W; Pan, W. J.; Gu, X. Y.; Zhang, S. Q.; Dawa, C; Yi, X; Ciwang, Z; Wang, Y; Li, S. Y.; Jiang, R. M. (2011). "Clinical features, diagnosis and treatment of 5 cases of primary pneumonic plague in Tibet in 2010". _Zhonghua jie he he hu xi za zhi_. 34 (6): 404–8. PMID 21781509 . * ^ Peru suffers deadly outbreak of bubonic and pneumonic plague, _The Telegraph_, August 3, 2010. Accessed November 4, 2014. * ^ http://blog.taragana.com/health/2010/08/02/perus-health-minister-says-plague-outbreak-has-killed-teenager-infected-at-least-31-people-25654/ * ^ http://www.theaustralian.com.au/news/world/pneumonic-plague-kills-39-in-madagascar/story-e6frg6so-1226782151149 * ^ http://www.bbc.co.uk/news/world-africa-25342122 * ^ " Bubonic plague \'worse than Black Death\' kills 39 in Madagascar", _South China Morning Post_, December 12, 2013. Accessed November 4, 2014. * ^ Plague emerges in Grand Canyon, kills biologist * ^ Coffman, Keith. Colorado Man Diagnosed With Rare Pneumonic Plague, _Business Insider_, July 10, 2014. Accessed November 4, 2014. * ^ Basak, Sonali; Oldham, Jennifer. Four Cases of Life-Threatening Plague Found in Colorado, _Bloomberg_, July 19, 2014. Accessed November 4, 2014. * ^ Kaplan, Sarah (May 1, 2015). "A Colorado pit bull infected humans with the plague". _Washington Post_. Retrieved 1 May 2015.