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PNEUMONIC PLAGUE is a severe lung infection caused by the bacterium Yersinia pestis
Yersinia pestis
. Symptoms include fever , headache, shortness of breath , chest pain , and cough. They typically start about three to seven days after exposure. It is one of three forms of plague , the other two being septicemic plague and bubonic plague .

The pneumonic form may occur following an initial bubonic or septicemic plague infection. It may also result from breathing in airborne droplets from another person or cat infected with pneumonic plague. The difference between the forms of plague is the location of infection; in pneumonic plague the infection is in the lungs, in bubonic plague the lymph nodes , and in septicemic plague within the blood. Diagnosis is by testing the blood, sputum, or fluid from a lymph node.

While vaccines are being worked on, in most countries they are not yet commercially available. Prevention is generally by avoiding contact with rodents . It is recommended that those infected be isolated from others. Treatment of pneumonic plague is with antibiotics .

Plague is present among rodents in Africa, the Americas, and Asia. Pneumonic plague
Pneumonic plague
is more serious and less common than bubonic plague. The total reported number of all types of plague in 2013 was 783. Untreated pneumonic plague has a mortality of nearly 100%. Some hypothesize that the pneumonic version of the plague was mainly responsible for the Black Death that resulted in approximately 50 million deaths in the 1300s.

CONTENTS

* 1 Signs and symptoms

* 2 Cause

* 2.1 Spread

* 3 Treatment

* 4 Epidemiology

* 4.1 India * 4.2 China * 4.3 Peru * 4.4 Madagascar
Madagascar
* 4.5 United States

* 5 References * 6 External links

SIGNS AND SYMPTOMS

The most apparent symptom of pneumonic plague is coughing, often with hemoptysis (coughing up blood). With pneumonic plague, the first signs of illness are fever, headache, weakness and rapidly developing pneumonia with shortness of breath, chest pain, cough and sometimes bloody or watery sputum .

The pneumonia progresses for two to four days and may cause respiratory failure and shock . Patients will die without early treatment, some within 36 hours.

Initial pneumonic plague symptoms can often include the following:

* Fever
Fever
* Weakness * Headaches
Headaches
* Nausea

Rapidly developing pneumonia with:

* Shortness of breath * Chest pain * Cough * Bloody or watery sputum (saliva and discharge from respiratory passages ).

CAUSE

SPREAD

Pneumonic plague
Pneumonic plague
can be caused in two ways: primary, which results from the inhalation of aerosolised plague bacteria , or secondary, when septicaemic plague spreads into lung tissue from the bloodstream. Pneumonic plague
Pneumonic plague
is not exclusively vector-borne like bubonic plague; instead it can be spread from person to person. There have been cases of pneumonic plague resulting from the dissection or handling of contaminated animal tissue. This is one type of the plague formerly known as the Black Death .

TREATMENT

Pneumonic plague
Pneumonic plague
is a very aggressive infection requiring early treatment. Antibiotics must be given within 24 hours of first symptoms to reduce the risk of death. Streptomycin
Streptomycin
, gentamicin , tetracyclines and chloramphenicol are all effective against pneumonic plague.

Antibiotic treatment for seven days will protect people who have had direct, close contact with infected patients. Wearing a close-fitting surgical mask also protects against infection.

The mortality rate from untreated pneumonic plague approaches 100%.

EPIDEMIOLOGY

Main article: Epidemiology of plague

Since 2002, the World Health Organization (WHO) has reported seven plague outbreaks, though some may go unreported because they often happen in remote areas. Between 1998 and 2009, nearly 24,000 cases have been reported, including about 2,000 deaths, in Africa
Africa
, Asia
Asia
, the Americas , and Eastern Europe . Ninety-eight percent of the world's cases occur in Africa.

INDIA

In September 1994, India experienced an outbreak of plague that killed 50 and caused travel to New Delhi by air to be suspended until the outbreak was brought under control. The outbreak was feared to be much worse because the plague superficially resembles other common diseases such as influenza and bronchitis; over 200 people that had been quarantined were released when they did not test positive for the plague. All but two of the deaths occurred around the city of Surat .

CHINA

The People\'s Republic of China has eradicated the pneumonic plague from most parts of the country, but still reports occasional cases in remote Western areas where the disease is carried by rats and the marmots that live across the Himalayan plateau . Outbreaks can be caused when a person eats an infected marmot or comes into contact with fleas carried by rats. A 2006 WHO report from an international meeting on plague cited a Chinese government disease expert as saying that most cases of the plague in China\'s northwest occur when hunters are contaminated while skinning infected animals.

The expert said at the time that due to the region's remoteness, the disease killed more than half the infected people. The report also said that since the 1990s, there was a rise in plague cases in humans—from fewer than 10 in the 1980s to nearly 100 cases in 1996 and 254 in 2000. Official statistics posted on the Chinese Health Ministry 's Web site showed no cases of plague in 2007 and 2008. In September 2008, two people in east Tibet died of pneumonic plague.

An outbreak of the disease in China began in August 2009 in Ziketan Town located in Qinghai Province
Qinghai Province
. The town was sealed off and several people died as a result of the disease. According to spokesperson Vivian Tan of the WHO office in Beijing
Beijing
, "In cases like this , we encourage the authorities to identify cases, to investigate any suspicious symptoms among close contacts, and to treat confirmed cases as soon as possible. So far, they have done exactly that. There have been sporadic cases reported around the country in the last few years so the authorities do have the experience to deal with this."

In September 2010, five cases of pneumonic plague were reported in Tibet.

In July 17, 2014, Chinese media reported one case found in Gansu.

PERU

In August 2010, Peru's health minister Oscar Ugarte announced that an outbreak of plague had killed a 14-year-old boy and had infected at least 31 people in a northern coastal province. The boy died of bubonic plague on 26 July 2010. Ugarte stated that authorities were screening sugar and fish meal exports from Ascope Province
Ascope Province
, located about 325 miles (520 km) northwest of Lima
Lima
, not far from popular Chicama beach . Most of the infections in Peru were bubonic plague, with four cases of pneumonic plague.

The first recorded plague outbreak in Peru was in 1903. The last, in 1994, killed 35 people.

MADAGASCAR

An outbreak of plague in November 2013, occurred in the African island nation of Madagascar
Madagascar
. As of 16 December, at least 89 people were infected, with 39 deaths with at least two cases involving pneumonic plague. However, as many as 90% of cases were later reported to have involved pneumonic plague. From 23 August to 30 September 2017, a total of 73 suspected, probable, and confirmed cases of pneumonic plague, including 17 deaths, were reported in Madagascar. The diagnosis was confirmed by the Institut Pasteur de Madagascar
Madagascar
by polymerase chain reaction test or using rapid diagnostic test. The WHO and Institut Pasteur were both involved in administering antibiotic compounds and attempting to stop the spread of the disease. By mid-October there were an estimated 684 confirmed cases of plague with 474 pneumonic, 156 bubonic and one septicaemic. The remainder were not classified. At least 74 deaths have been credited to pneumonic plague.

UNITED STATES

On November 2, 2007, wildlife biologist Eric York died of pneumonic plague in Grand Canyon National Park
Grand Canyon National Park
. York was exposed to the bacteria while conducting a necropsy on a mountain lion carcass.

On July 10, 2014, in an online news story article, by Keith Coffman of Reuters
Reuters
, featured on the MSN U.S. News website, it was stated that a Colorado man, whose condition the report said was not known, had been diagnosed with the pneumonic plague. The man was found to have the disease after the family dog died unexpectedly and a necropsy conducted on it revealed it had died from the disease, which is spread when fleas which have been hosted by rodents (mostly prairie dogs) spread to another nearby host once the original one dies. The plague is found in the western US.

As of July 18, 2014, three more cases were reported in Colorado. However, the outbreak appears to be over, according to state officials. The outbreak was caused by a pit bull .

REFERENCES

* ^ A B C D E F G H I "FAQ Plague". www.cdc.gov. Archived from the original on 14 March 2017. Retrieved 13 March 2017. * ^ A B C D E F "Plague". World Health Organization. September 2016. Archived from the original on 24 April 2015. Retrieved 14 March 2017. * ^ A B C D E F G H I J "Plague". www.who.int. Archived from the original on 19 March 2017. Retrieved 14 March 2017. * ^ McCoy, Terrence (31 March 2014). "Everything you know about the Black Death is wrong". Washington Post. The Washington Post. Archived from the original on 27 August 2016. Retrieved 14 March 2017. * ^ A B C Facts about Pneumonic Plague (Center for Disease Control, 2004) Archived 2013-08-02 at the Wayback Machine . * ^ Benedictow, Ole Jørgen (2004). The Black Death, 1346–1353: The Complete History. Boydell & Brewer. pp. 27–28. ISBN 0-85115-943-5 . * ^ Plague Archived 2017-01-31 at the Wayback Machine .. (Iowa State University, 2004) * ^ Plague Fears Cancel Flights. The Daily Gleaner, October 1, 1994. * ^ Plague Fears Beginning to Recede. The Daily Gleaner, October 2, 1994. * ^ A B "China disinfects town where plague killed 3rd man". Associated Press. 2009-08-04. Archived from the original on 2009-08-08. * ^ Macartney, Jane (August 3, 2009). Entire town in quarantine after two die from pneumonic plague in China Archived 2011-04-29 at the Wayback Machine .. The Times (London). * ^ Two deaths from rare, deadly plague in Tibet Archived 2009-11-14 at the Wayback Machine . * ^ "4th plague patient near death in NW China province". Xinhua. 2009-08-05. Archived from the original on 2009-08-08. * ^ Alert over China plague outbreak Archived 2009-08-03 at the Wayback Machine .. Al Jazeera . August 3, 2009. * ^ Dawa, W; Pan, W. J.; Gu, X. Y.; Zhang, S. Q.; Dawa, C; Yi, X; Ciwang, Z; Wang, Y; Li, S. Y.; Jiang, R. M. (2011). "Clinical features, diagnosis and treatment of 5 cases of primary pneumonic plague in Tibet in 2010". Zhonghua jie he he hu xi za zhi. 34 (6): 404–8. PMID 21781509 . * ^ Peru suffers deadly outbreak of bubonic and pneumonic plague Archived 2013-02-04 at the Wayback Machine ., The Telegraph, August 3, 2010. Accessed November 4, 2014. * ^ "Archived copy". Archived from the original on 2010-08-17. Retrieved 2010-08-03. * ^ http://www.theaustralian.com.au/news/world/pneumonic-plague-kills-39-in-madagascar/story-e6frg6so-1226782151149 * ^ "Archived copy". Archived from the original on 2013-12-16. Retrieved 2013-12-16. * ^ " Bubonic plague
Bubonic plague
\'worse than Black Death\' kills 39 in Madagascar" Archived 2013-12-16 at the Wayback Machine ., South China Morning Post, December 12, 2013. Accessed November 4, 2014. * ^ "Plague – Madagascar
Madagascar
Disease outbreak news". Retrieved 2017-10-05. * ^ Beaumont, Peter (October 19, 2017). "\'It is a dangerous moment\': Madagascar
Madagascar
plague death toll reaches 74". The Guardian. * ^ Plague emerges in Grand Canyon, kills biologist Archived 2012-04-19 at the Wayback Machine . * ^ Coffman, Keith. Colorado Man Diagnosed With Rare Pneumonic Plague Archived 2014-11-04 at the Wayback Machine ., Business Insider, July 10, 2014. Accessed November 4, 2014. * ^ Basak, Sonali; Oldham, Jennifer. Four Cases of Life-Threatening Plague Found in Colorado Archived 2015-01-14 at the Wayback Machine ., Bloomberg, July 19, 2014. Accessed November 4, 2014. * ^ Kaplan, Sarah (May 1, 2015). "A Colorado pit bull infected humans with the plague". Washington Post. Archived from the original on 1 May 2015. Retrieved 1 May 2015.

EXTERNAL

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