The platelet-activating factor receptor (PAF-R) is a
G-protein coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
which binds
platelet-activating factor.
It is encoded in the human by the ''PTAFR''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.
upplied by OMIMref name="entrez"> Its pathogenetic role in chronic kidney failure has also been reported recently.
Ligands
Agonists
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Platelet activating factor
Antagonists
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Apafant (WEB-2086)
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Israpafant (Y-24180)
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Lexipafant
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Rupatadine
Rupatadine is a second generation antihistamine and platelet-activating factor antagonist used to treat allergies. It was discovered and developed by and is marketed as Rupafin and under several other trade names.
Medical uses
Rupatadine fum ...
References
Further reading
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External links
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G protein-coupled receptors
{{transmembranereceptor-stub