Plakophilin are proteins of the cytoskeleton. They are involved in regulating the adhesive activity of
cadherin
Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to allow cells to adhere to each other . Cadherins are a class of type-1 transmembrane proteins, ...
.
The three types of plakophilin proteins found in humans are
PKP1
Plakophilin-1 is a protein that in humans is encoded by the ''PKP1'' gene.
Function
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cel ...
,
PKP2
Plakophilin-2 is a protein that in humans is encoded by the ''PKP2'' gene. Plakophilin 2 is expressed in skin and cardiac muscle, where it functions to link cadherins to intermediate filaments in the cytoskeleton. In cardiac muscle, plakophilin-2 ...
, and
PKP3; all exhibiting dual localization in the nucleus as well as desmosomes.
Genes include:
*
PKP1
Plakophilin-1 is a protein that in humans is encoded by the ''PKP1'' gene.
Function
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cel ...
*
PKP2
Plakophilin-2 is a protein that in humans is encoded by the ''PKP2'' gene. Plakophilin 2 is expressed in skin and cardiac muscle, where it functions to link cadherins to intermediate filaments in the cytoskeleton. In cardiac muscle, plakophilin-2 ...
*
PKP3
See also
*
References
Protein families
Cytoskeleton
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