A plakin is a protein that associates with
junctional complexes and the
cytoskeleton
The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea. In eukaryotes, it extends from the cell nucleus to the cell membrane and is com ...
.
Types include
desmoplakin
Desmoplakin is a protein in humans that is encoded by the ''DSP'' gene. Desmoplakin is a critical component of desmosome structures in cardiac muscle and epidermal cells, which function to maintain the structural integrity at adjacent cell conta ...
,
envoplakin
Envoplakin is a protein that in humans is encoded by the ''EVPL'' gene.
Interactions
Envoplakin has been shown to interact
Advocates for Informed Choice, doing business as, dba interACT or interACT Advocates for Intersex Youth, is a 501(c) ...
,
periplakin,
plectin
Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton ...
,
bullous pemphigoid antigen 1,
corneodesmosin
Corneodesmosin is a protein that in humans is encoded by the ''CDSN'' gene.
This gene encodes a protein found in corneodesmosomes, which localize to the human epidermis and other cornified squamous epithelia. During maturation of the cornified lay ...
, and
microtubule actin cross-linking factor.
References
Protein families
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