PipISB is a drug used in scientific research which acts as a potent and selective inverse agonist of the

cannabinoid receptor Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid recep ...

CB₁. It is highly selective for the CB₁ receptor over CB₂, with a K_d at CB₁ of 1.5nM vs over 7000nM at CB₂, has good blood–brain barrier penetration, and can be conveniently

radiolabelled Isotopic labeling (or isotopic labelling) is a technique used to track the passage of an isotope (an atom with a detectable variation in neutron count) through a reaction, metabolic pathway, or cell. The reactant is 'labeled' by replacing specific ...

with either ¹¹C or ¹⁸F, making it useful for mapping the distribution of CB₁ receptors in the brain.

References

Cannabinoids CB1 receptor antagonists {{cannabinoid-stub