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Pinacidil is a cyanoguanidine drug that opens
Condensation of 4-isothiocyanotopyridine 6105-84-5(1) and 3,3-dimethyl-2-butanamine 850-30-4(2) gives thiourea 7027-06-9(3). Treatment of that intermediate with a mixture of triphenylphosphine, carbon tetrachloride, and triethylamine leads to the unsymmetrical carbodiimide
CID:20501933
(4'). Addition of cyanamid affords pinacidil (5).
ATP-sensitive potassium channel
An ATP-sensitive potassium channel (or KATP channel) is a type of potassium channel that is gated by intracellular nucleotides, ATP and ADP. ATP-sensitive potassium channels are composed of Kir6.x-type subunits and sulfonylurea receptor (SUR) ...
s producing peripheral vasodilatation
Vasodilation is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. The process is the opposite of vasoconstriction, ...
of arteriole
An arteriole is a small-diameter blood vessel in the microcirculation that extends and branches out from an artery and leads to capillaries.
Arterioles have muscular walls (usually only one to two layers of smooth muscle cells) and are the primar ...
s. It reduces blood pressure
Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure" r ...
and peripheral resistance and produces fluid retention.
Synthesis
Condensation of 4-isothiocyanotopyridine 6105-84-5(1) and 3,3-dimethyl-2-butanamine 850-30-4(2) gives thiourea 7027-06-9(3). Treatment of that intermediate with a mixture of triphenylphosphine, carbon tetrachloride, and triethylamine leads to the unsymmetrical carbodiimideCID:20501933
(4'). Addition of cyanamid affords pinacidil (5).
References
External links
* Potassium channel openers 4-Pyridyl compounds Cyanamides {{cardiovascular-drug-stub