Pierre Chambon (born 7 February 1931 in

Mulhouse, France Mulhouse (; Alsatian language, Alsatian: or , ; ; meaning ''Mill (grinding), mill house'') is a city of the Haut-Rhin Departments of France, department, in the Grand Est Regions of France, region, eastern France, close to the France–Switzerl ...

) was the founder of the in

Strasbourg Strasbourg (, , ; german: Straßburg ; gsw, label= Bas Rhin Alsatian, Strossburi , gsw, label= Haut Rhin Alsatian, Strossburig ) is the prefecture and largest city of the Grand Est region of eastern France and the official seat of the ...

France France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pac ...

. He was one of the leading molecular biologists who utilized gene cloning and sequencing technology to first decipher the structure of eukaryotic genes and their modes of regulation. His major contributions to science include the identification of RNA polymerase II(B), the identification of transcriptional control elements, the cloning and dissection of nuclear hormone receptors, revealing their structure and showing how they contribute to human

physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemic ...

. His group was also one of the first to demonstrate, biochemically and electron-microscopically, that the nucleosome is the smallest unit of chromatin (Cell, Vol. 4, 281–300, 1975). He accomplished much of his work in the 1970-90s. Chambon was elected a Foreign Associate of the US National Academy of Sciences and to the French

Académie des Sciences The French Academy of Sciences (French: ''Académie des sciences'') is a learned society, founded in 1666 by Louis XIV at the suggestion of Jean-Baptiste Colbert, to encourage and protect the spirit of French scientific research. It was at ...

in 1985, a foreign member of the Royal Swedish Academy of Sciences in 1987. He was awarded the

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemis ...

from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

in 1999 and a second time in 2018. In 2003 he was awarded the March of Dimes Prize in Developmental Biology. He received the

Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 5 ...

in 2004 for his work in the field. In 2010, Chambon was awarded the Gairdner Foundation International Award "for the elucidation of fundamental mechanisms of transcription in animal cells and to the discovery of the nuclear receptor superfamily". In 2018 he received the

for a second time.Louisa Gross Horwitz Prize 2018
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Notes

References

External links

The Official Site of Louisa Gross Horwitz Prize

ISI Highly Cited page
Living people 1931 births Collège de France faculty Foreign associates of the National Academy of Sciences Members of the French Academy of Sciences Members of the Royal Swedish Academy of Sciences French molecular biologists French geneticists French endocrinologists French people of Jewish descent Scientists from Mulhouse University of Strasbourg alumni Recipients of the Albert Lasker Award for Basic Medical Research Fellows of the AACR Academy Commandeurs of the Légion d'honneur Grand Officers of the Ordre national du Mérite Richard-Lounsbery Award laureates {{biologist-stub