In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a phosphoadenylylsulfatase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:3'-phosphoadenylyl sulfate + H
2O
adenosine 3',5'-bisphosphate + sulfate
Thus, the two
substrates of this enzyme are
3'-phosphoadenylyl sulfate and
H2O, whereas its two
products are
adenosine 3',5'-bisphosphate
Adenosine 3',5'-bisphosphate is a form of an adenosine nucleotide with two phosphate groups attached to different carbons in the ribose ring. This is distinct from adenosine diphosphate, where the two phosphate groups are attached in a chain to th ...
and
sulfate.
This enzyme belongs to the family of
hydrolases, specifically those acting on acid anhydrides in sulfonyl-containing anhydrides. The
systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate sulfohydrolase. Other names in common use include 3-phosphoadenylyl sulfatase, 3-phosphoadenosine 5-phosphosulfate sulfatase, PAPS sulfatase, and 3'-phosphoadenylylsulfate sulfohydrolase. This enzyme participates in
sulfur metabolism. It employs one
cofactor,
manganese.
References
*
EC 3.6.2
Manganese enzymes
Enzymes of unknown structure
{{3.6-enzyme-stub