Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the

central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all p ...

. It has been found to trigger dopamine release in the

nucleus accumbens The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the ''nucleus accumbens septi'', Latin for " nucleus adjacent to the septum") is a region in the basal forebrain rostral to the preoptic area of the hypot ...

of rats.

Derivatives

*Phenylbiguanide is used to make amanozine and benfosformin.

References

5-HT3 agonists Biguanides {{pharmacology-stub