epidemiology Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evide ...

, prevalence is the proportion of a particular population found to be affected by a medical condition (typically a disease or a risk factor such as smoking or seatbelt use) at a specific time. It is derived by comparing the number of people found to have the condition with the total number of people studied and is usually expressed as a fraction, a percentage, or the number of cases per 10,000 or 100,000 people. Prevalence is most often used in

questionnaire A questionnaire is a research instrument that consists of a set of questions (or other types of prompts) for the purpose of gathering information from respondents through survey or statistical study. A research questionnaire is typically a mix of ...

studies.

Difference between prevalence and incidence

Prevalence is the number of disease cases ''present ''in a particular population at a given time, whereas incidence is the number of new cases that ''develop '' during a specified time period. Prevalence answers "How many people have this disease right now?" or "How many people have had this disease during this time period?". Incidence answers "How many people acquired the disease uring a specified time period". However, mathematically, prevalence is proportional to the product of the incidence and the average duration of the disease. In particular, when the prevalence is low (<10%), the relationship can be expressed as: :

Prevalence = incidence \times duration

Caution must be practiced as this relationship is only applicable when the following two conditions are met: 1) prevalence is low and 2) the duration is constant (or an average can be taken). A general formulation requires

differential equation In mathematics, a differential equation is an equation that relates one or more unknown functions and their derivatives. In applications, the functions generally represent physical quantities, the derivatives represent their rates of change, an ...

Examples and utility

In science, ''prevalence'' describes a proportion (typically expressed as a percentage). For example, the prevalence of obesity among American adults in 2001 was estimated by the U. S. Centers for Disease Control (CDC) at approximately 20.9%. Prevalence is a term that means being widespread and it is distinct from incidence. Prevalence is a measurement of ''all'' individuals affected by the disease at a particular time, whereas incidence is a measurement of the number of ''new'' individuals who contract a disease during a particular period of time. Prevalence is a useful parameter when talking about long-lasting diseases, such as

HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

, but incidence is more useful when talking about diseases of short duration, such as chickenpox.

Uses

Lifetime prevalence

Lifetime prevalence (LTP) is the proportion of individuals in a population that at some point in their life (up to the time of assessment) have experienced a "case", e.g., a disease; a traumatic event; or a behavior, such as committing a crime. Often, a 12-month prevalence (or some other type of "period prevalence") is provided in conjunction with lifetime prevalence. ''Point prevalence'' is the prevalence of disorder at a specific point in time (a month or less). ''Lifetime morbid risk'' is "the proportion of a population that might become afflicted with a given disease at any point in their lifetime."

Period prevalence

Period prevalence is the proportion of the population with a given disease or condition over a specific period of time. It could describe how many people in a population had a cold over the cold season in 2006, for example. It is expressed as a percentage of the population and can be described by the following formula: Period prevalence (proportion) = Number of cases that existed in a given period ÷ Number of people in the population during this period The relationship between incidence (rate), point prevalence (ratio) and period prevalence (ratio) is easily explained via an analogy with photography. Point prevalence is akin to a flashlit photograph: what is happening at this instant frozen in time. Period prevalence is analogous to a long exposure (seconds, rather than an instant) photograph: the number of events recorded in the photo whilst the camera shutter was open. In a movie each frame records an instant (point prevalence); by looking from frame to frame one notices new events (incident events) and can relate the number of such events to a period (number of frames); see

incidence rate In epidemiology, incidence is a measure of the probability of occurrence of a given medical condition in a population within a specified period of time. Although sometimes loosely expressed simply as the number of new cases during some time peri ...

Point prevalence

Point prevalence is a measure of the proportion of people in a population who have a disease or condition at a particular time, such as a particular date. It is like a snapshot of the disease in time. It can be used for statistics on the occurrence of

chronic diseases A chronic condition is a health condition or disease that is persistent or otherwise long-lasting in its effects or a disease that comes with time. The term ''chronic'' is often applied when the course of the disease lasts for more than three mon ...

. This is in contrast to period prevalence which is a measure of the proportion of people in a population who have a disease or condition over a specific period of time, say a season, or a year. Point prevalence can be described by the formula: Prevalence = Number of existing cases on a specific date ÷ Number of people in the population on this date

Limitations

It can be said that a very small error applied over a very large number of individuals (that is, those who are ''not affected'' by the condition in the general population during their lifetime; for example, over 95%) produces a relevant, non-negligible number of subjects who are incorrectly classified as having the condition or any other condition which is the object of a survey study: these subjects are the so-called false positives; such reasoning applies to the 'false positive' but not the 'false negative' problem where we have an error applied over a relatively very small number of individuals to begin with (that is, those who are ''affected'' by the condition in the general population; for example, less than 5%). Hence, a very high percentage of subjects who seem to have a history of a disorder at interview are false positives for such a medical condition and apparently never developed a fully clinical

syndrome A syndrome is a set of medical signs and symptoms which are correlated with each other and often associated with a particular disease or disorder. The word derives from the Greek language, Greek σύνδρομον, meaning "concurrence". When a sy ...

. A different but related problem in evaluating the public health significance of psychiatric conditions has been highlighted by Robert Spitzer of

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

: fulfillment of

diagnostic criteria Medical diagnosis (abbreviated Dx, Dx, or Ds) is the process of determining which disease or condition explains a person's symptoms and signs. It is most often referred to as diagnosis with the medical context being implicit. The information req ...

and the resulting

diagnosis Diagnosis is the identification of the nature and cause of a certain phenomenon. Diagnosis is used in many different disciplines, with variations in the use of logic, analytics, and experience, to determine " cause and effect". In systems engin ...

do not necessarily imply need for treatment. A well-known statistical problem arises when ascertaining rates for disorders and conditions with a relatively low population prevalence or

base rate In probability and statistics, the base rate (also known as prior probabilities) is the class of probabilities unconditional on "featural evidence" (likelihoods). For example, if 1% of the population were medical professionals, and remaining ...

. Even assuming that lay interview diagnoses are highly accurate in terms of sensitivity and specificity and their corresponding area under the

ROC curve A receiver operating characteristic curve, or ROC curve, is a graphical plot that illustrates the diagnostic ability of a binary classifier system as its discrimination threshold is varied. The method was originally developed for operators of m ...

(that is, AUC, or area under the

receiver operating characteristic A receiver operating characteristic curve, or ROC curve, is a graphical plot that illustrates the diagnostic ability of a binary classifier system as its discrimination threshold is varied. The method was originally developed for operators of m ...

curve), a condition with a relatively low prevalence or base-rate is bound to yield high

false positive A false positive is an error in binary classification in which a test result incorrectly indicates the presence of a condition (such as a disease when the disease is not present), while a false negative is the opposite error, where the test resul ...

rates, which exceed

false negative A false positive is an error in binary classification in which a test result incorrectly indicates the presence of a condition (such as a disease when the disease is not present), while a false negative is the opposite error, where the test resul ...

rates; in such a circumstance a limited positive predictive value, PPV, yields high

rates even in presence of a specificity which is very close to 100%.

References

External links

PlusNews, the UN's HIV/AIDS news service provides HIV prevalence rates for nearly 60 countries worldwide

Synopsis of article on "How Prevalent Is Schizophrenia?" from Public Library of Science

Prevalance of COVID-19 outbreak
{{Authority control Epidemiology Medical statistics Statistical ratios