Paul Ahlquist is an American virologist who is Professor of Molecular Virology and Oncology at the University of Wisconsin–Madison.

Education

Ahlquist earned his B.S. in physics from Iowa State University and his Ph.D. in biophysics from the University of Wisconsin–Madison. His research is focused on the

gene expression Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. The ...

RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...

viruses.

Honors and awards

Ahlquist was admitted to the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

in 1993 and has been a

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...

(HHMI) investigator since 1997.

Research

His work at the University of Wisconsin-Madison focuses on molecular mechanisms of viral replication, host interactions, and oncogenesis.

Recent publications

*Giménez-Barcons, M., Alves-Rodrigues, I., Jungfleisch, J., Van Wynsberghe, P. M., Ahlquist, P., and Díez, J. The Cellular Decapping Activators LSm1, Pat1, and Dhh1 Control the Ratio of Subgenomic to Genomic Flock House Virus RNAs. J. Virol., 87(11): 6192-6200, 2013. *Seidel, S., Bruce, J., Leblanc, M., Lee, K.-F., Fan, H., Ahlquist, P., and Young, J. A. T. ZASC1 Knockout Mice Exhibit an Early Bone Marrow-Specific Defect in Murine Leukemia Virus Replication. Virol. J., 10(1): 130, 2013. *Diaz, A., and Ahlquist, P. Role of Host Reticulon Proteins in Rearranging Membranes for Positive-Strand RNA Virus Replication. Curr. Opin. Microbiol., 15: 519-524, 2012. *Diaz, A., Gallei, A., and Ahlquist, P. Bromovirus RNA Replication Compartment Formation Requires Concerted Action of 1a’s Self-Interacting RNA Capping and Helicase Domains. J. Virol., 86: 821-834, 2012. *Huang, H.-S., Pyeon, D., Pearce, S. M., Lank, S. M., Griffin, L. M., Ahlquist, P., and Lambert, P. F. Novel Antivirals Inhibit Early Steps in HPV Infection. Antiviral Res., 93: 280-287, 2012. *Wen, Z., Pyeon, D., Wang, Y., Lambert, P., Xu, W., and Ahlquist, P. Orphan Nuclear Receptor PNR/NR2E3 Stimulates p53 Functions by Enhancing p53 Acetylation. Mol. Cell. Biol., 32: 26-35, 2012. *Zhang, J., Diaz, A., Mao, L., Ahlquist, P., and Wang, X. Host Acyl Coenzyme A Binding Protein Regulates Replication Complex Assembly and Activity of a Positive-Strand RNA Virus. J. Virol., 86: 5110-5121, 2012. *Gancarz, B. L., Hao, L., He, Q., Newton, M. A., and Ahlquist, P. Systematic Identification of Novel, Essential Host Genes Affecting Bromovirus RNA Replication. PLoS One, 6(8):e23988, 2011. *Scholthof, K.-B. G., Adkins, S., Czosnek, H., Palukaitis, P., Jacquot, E., Hohn, T., Hohn, B., Saunders, K., Candresse, T., Ahlquist, P., Hemenway, C., and Foster, G. D. Top 10 Plant Viruses in Molecular Plant Pathology. Mol. Plant Pathol., 12: 938-954, 2011. *Wang, X., Diaz, A., Hao, L., Gancarz, B., den Boon, J. A., and Ahlquist, P. Intersection of the Multivesicular Body Pathway and Lipid Homeostasis in RNA Replication by a Positive-Strand RNA Virus. J. Virol., 85: 5494-5503, 2011.

References

External links

His academic home page
{{DEFAULTSORT:Ahlquist, Paul Living people Members of the United States National Academy of Sciences American virologists Howard Hughes Medical Investigators Year of birth missing (living people)