''para''-Iodoamphetamine (PIA), also known as 4-iodoamphetamine (4-IA), is a research chemical of the phenethylamine and amphetamine

chemical class Chemical classification systems attempt to classify elements or compounds according to certain chemical functional or structural properties. Whereas the structural properties are largely intrinsic, functional properties and the derived classificat ...

es. It acts as a selective serotonin

releasing agent A monoamine releasing agent (MRA), or simply monoamine releaser, is a drug that induces the synapse, release of a monoamine neurotransmitter from the synapse, presynaptic neuron into the synapse, leading to an increase in the extracellular conc ...

and is also a

MAOI Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressants, especia ...

. PIA is rumored to be a serotonergic neurotoxin on the account of that being reported to be the case for ''para''-chloroamphetamine. However, PIA is a much weaker 5-HT neurotoxin than is the case for PCA.

Analogs

5-IAI was an attempt to make a non-neurotoxic analog of PIA.

References

Neurotoxins Substituted amphetamines Iodoarenes Serotonin-norepinephrine-dopamine releasing agents {{Neurotoxin-stub

Analogs

See also

References