''para''-Bromoamphetamine (PBA), also known as 4-bromoamphetamine (4-BA), is an

amphetamine Amphetamine (contracted from alpha- methylphenethylamine) is a strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. It is also commonly used ...

derivative which acts as a

serotonin Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vas ...

norepinephrine Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin '' ad'', ...

dopamine Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic compound, organic chemical of the catecholamine and phenethylamine families. Dopamine const ...

releasing agent A monoamine releasing agent (MRA), or simply monoamine releaser, is a drug that induces the synapse, release of a monoamine neurotransmitter from the synapse, presynaptic neuron into the synapse, leading to an increase in the extracellular conc ...

(SNDRA) and produces

stimulant Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and inv ...

effects. Another related compound is para-bromomethamphetamine known by the codename V-111.Magyar K, Tekes K, Zólyomi G, Szüts T, Knoll J. The fate of p-bromo-methylamphetamine (V-111) in the body. Acta Physiol Acad Sci Hung. 1981;57(3):285-307. PMID: 7304194.

Neurotoxicity

Like most other ''

para Para, or PARA, may refer to: Businesses and organizations * Paramount Global, traded as PARA on the Nasdaq stock exchange * Para Group, the former name of CT Corp * Para Rubber, now Skellerup, a New Zealand manufacturer * Para USA, formerly ...

''-

substituted A substitution reaction (also known as single displacement reaction or single substitution reaction) is a chemical reaction during which one functional group in a chemical compound is replaced by another functional group. Substitution reactions ar ...

s, PBA can be

neurotoxic Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. It occurs when exposure to a substance – specificall ...

and may deplete the brain of 5-hydroxyindoles for at least a week.

References

Neurotoxins Substituted amphetamines Bromoarenes Serotonin-norepinephrine-dopamine releasing agents {{Neurotoxin-stub

Neurotoxicity

See also

References