Papuloerythroderma of Ofuji is a rare disorder most commonly found in Japan, characterized by pruritic
papules that spare the skinfolds, producing bands of uninvolved cutis, creating the so-called deck-chair sign. Frequently there is associated blood eosinophilia. Skin biopsies reveal a dense lymphohistiocytic infiltrate,
eosinophils in the papillary dermis, and increased
Langerhans cells
A Langerhans cell (LC) is a tissue-resident macrophage of the skin. These cells contain organelles called Birbeck granules. They are present in all layers of the epidermis and are most prominent in the stratum spinosum. They also occur in the ...
(S-100 positive). Systemic steroids are the treatment of choice and may result in long-term remissions.
It was characterized in 1984.
Use of PUVA in treatment has been described.
See also
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Pruritus
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List of cutaneous conditions
Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against t ...
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Erythroderma
References
External links
Eosinophilic cutaneous conditions
{{Cutaneous-condition-stub