PWZ-029 is a benzodiazepine derivative drug with

nootropic Nootropics ( , or ) (colloquial: smart drugs and cognitive enhancers, similar to adaptogens) are a wide range of natural or synthetic dietary supplement, supplements or drugs and other substances that are claimed to improve cognitive function ...

effects developed by WiSys,US Patent application US2006/258643 A1 It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABA_A

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

, acting as a partial inverse agonist at the α₅ subtype and a weak

partial agonist In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...

at the α₃ subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no

convulsant A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs generally act as stimulants at low doses, but are not used for this purpose due to the risk of convulsions and consequent e ...

or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.

References

Chloroarenes Ethers GABAA receptor negative allosteric modulators Imidazobenzodiazepines Lactams Nootropics {{Nervous-system-drug-stub

See also

References