Polymerase I and transcript release factor, also known as Cavin1, Cavin-1 or PTRF, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
which in humans is encoded by the ''PTRF''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
PTRF (Cavin1) has been shown to be crucial for
caveola formation and function.
Termination of
RNA polymerase I catalyzed
transcription is a 2-step process that involves pausing of transcription elongation and release of both the pre-
ribosomal RNA
Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed from riboso ...
and Pol I from the
DNA template. The pausing is mediated by
TTF1
Transcription termination factor 1 is a protein that in humans is encoded by the ''TTF1'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gene ...
and PTRF.
PTRF is a soluble protein containing putative
leucine zipper,
nuclear localization signal, and
PEST domains.
Interactions
PTRF (Cavin1) forms trimers with Cavin2 and Cavin3 in caveola formation and has been shown to interact with other membrane associating proteins such as
EHD2 and
caveolins.
PTRF has been shown to
interact
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with
ZNF148.
References
Further reading
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