PHCCC is a research drug which acts as a
glutamate receptor
Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells. Glutamate (the conjugate base of glutamic acid) is abundant in the human body, but particularly in the nervous system ...
ligand, particularly being a
positive allosteric modulator at the
mGluR4 subtype,
as well as an agonist at
mGluR6.
It has anxiolytic effects in animal studies.
PHCCC and similar drugs have been suggested as novel treatments for
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms beco ...
.
See also
*
CPCCOEt
CPCCOEt is a drug used in scientific research, which acts as a non-competitive antagonist at the metabotropic glutamate receptor subtype mGluR1, with high selectivity although only moderate binding affinity
In biochemistry and pharmacology ...
References
Cyclopropanes
MGlu4 receptor agonists
Ketoximes
Anilides
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