PF-514273 is a drug developed by Pfizer, which acts as an extremely selective

antagonist An antagonist is a character in a story who is presented as the chief foe of the protagonist. Etymology The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, riv ...

for the CB₁

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

, with approximately 10,000x selectivity over the closely related CB₂ receptor. This very high selectivity makes it useful for scientific research into these receptors, as many commonly used cannabinoid receptor antagonists also block the CB₂ receptor to some extent.

References

Cannabinoids CB1 receptor antagonists Drugs developed by Pfizer {{cannabinoid-stub