RefSeq (protein)



Location (UCSC) Chr 6: 32.18 – 32.19 Mb Chr 17: 34.59 – 34.6 Mb PubMed search [3] [4] Wikidata
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Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[5][6]


This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[6]


PBX2 has been shown to interact with HOXA9.[7]


  1. ^ a b c ENSG00000237344, ENSG00000236353, ENSG00000232005, ENSG00000225987, ENSG00000206315, ENSG00000204304 GRCh38: Ensembl release 89: ENSG00000224952, ENSG00000237344, ENSG00000236353, ENSG00000232005, ENSG00000225987, ENSG00000206315, ENSG00000204304 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034673 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Sep 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890. 
  6. ^ a b "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2". 
  7. ^ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. PMC 84099Freely accessible. PMID 10082572. 

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.