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NM_006193

NM_001159925
NM_001159926
NM_011038

RefSeq (protein)

NP_006184

NP_001153397
NP_001153398
NP_035168

Location (UCSC) Chr 7: 127.61 – 127.62 Mb Chr 6: 28.44 – 28.45 Mb PubMed search [3] [4] Wikidata
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Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.[5][6][7]

Function

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box gene 4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106331 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029706 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: PAX4 paired box gene 4". 
  6. ^ Matsushita T, Yamaoka T, Otsuka S, Moritani M, Matsumoto T, Itakura M (Jan 1998). "Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4". Biochemical and Biophysical Research Communications. 242 (1): 176–80. doi:10.1006/bbrc.1997.7935. PMID 9439631. 
  7. ^ Inoue H, Nomiyama J, Nakai K, Matsutani A, Tanizawa Y, Oka Y (Feb 1998). "Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue". Biochemical and Biophysical Research Communications. 243 (2): 628–33. doi:10.1006/bbrc.1998.8144. PMID 9480859. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.