P. S. Dupont High School is a historic high school building located at Wilmington, Delaware, Wilmington, New Castle County, Delaware. It was built in 1934, and is a four-story, "E"-shaped, red brick building in a Colonial Revival architecture, Colonial Revival / Georgian architecture, Neo-Georgian style. It has a Hip roof, hipped roof covered with dark reddish-brown shingles, topped by a wood, three-level tower and cupola that ends in a multiple-sided, bell-like copper roof and weather vane. The school is named for Pierre S. du Pont (1870–1954). and It was one of three traditional public high schools in Wilmington, and initially did not accept black students, who were required to go to Howard High School. It was disestablished after Wilmington was divided into multiple school districts in the 1980s. It was added to the National Register of Historic Places in 1986. The school is currently used as a middle school in the Brandywine School District.

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School buildings on the National Register of Historic Places in Delaware Colonial Revival architecture in Delaware School buildings completed in 1934 Schools in Wilmington, Delaware National Register of Historic Places in Wilmington, Delaware Public Works Administration in Delaware 1934 establishments in Delaware Public high schools in Delaware {{Delaware-school-stub