Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification. Although osteoclasts are active during the natural formation of healthy bone the term "osteolysis" specifically refers to a pathological process. Osteolysis often occurs in the proximity of a prosthesis that causes either an immunological response or changes in the bone's structural load. Osteolysis may also be caused by pathologies like bone tumors, cysts, or chronic inflammation.
1 Joint replacement 2 Distal clavicular osteolysis 3 See also 4 References
While bone resorption is commonly associated with many diseases or
joint problems, the term osteolysis generally refers to a problem
common to artificial joint replacements such as total hip
replacements, total knee replacements and total shoulder
Osteolysis can also be associated with the
radiographic changes seen in those with bisphosphonate-related
osteonecrosis of the jaw.
There are several biological mechanisms which may lead to osteolysis.
In total hip replacement, the generally accepted explanation for
osteolysis involves wear particles (worn off the contact surface of
the artificial ball and socket joint). As the body attempts to clean
up these wear particles (typically consisting of plastic or metal), it
triggers an autoimmune reaction which causes resorption of living bone
Osteolysis has been reported to occur as early as 12 months
after implantation and is usually progressive. This may require a
revision surgery (replacement of the prosthesis).
Although osteolysis itself is clinically asymptomatic, it can lead to
implant loosening or bone breakage, which in turn causes serious
Distal clavicular osteolysis
Distal clavicular osteolysis (DCO) is often associated with problems
weightlifters have with their acromioclavicular joints due to high
stresses put on the clavicle as it meets with the acromion. This
condition is often referred to as "weight lifter's shoulder".
^ Osteolysis "Hip and Knee Replacements". Retrieved 10 April 2012. ^ Sanjeev Agarwal (2004). " Osteolysis - basic science, incidence and diagnosis". Current Orthopaedics. 18: 220–231. doi:10.1016/j.cuor.2004.03.002. ^ a b Schwarzkopf R, Ishak C, Elman M, Gelber J, Strauss DN, Jazrawi LM (2008). "Distal clavicular osteolysis: a review of the literature". Bull NYU Hosp Jt Dis. 66 (2): 94–101. PMID 18537776. Archived from the original on March 4, 2016. [A Review of Weight-Lifter's Shoulder Lay summary] Check laysummary= value (help) – eOrthopod. ^ Arend CF. Ultrasound of the Shoulder. Master Medical Books, 2013. Sample chapter available at ShoulderUS.com
v t e
Osteitis fibrosa cystica
Sesamoiditis Brodie abscess Periostitis Vertebral osteomyelitis
Osteopenia Osteomalacia Paget's disease of bone
Osteolysis Hajdu-Cheney syndrome Ainhum
Algoneurodystrophy Hypertrophic pulmonary osteoarthropathy Nonossifying fibroma Pseudarthrosis Stress fracture Fibrous dysplasia
Skeletal fluorosis bone cyst
Aneurysmal bone cyst
Infantile cortical hyperostosis
Osgood-Schlatter disease Blount's disease
Köhler disease Sever's disease
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