ORG-26576 is an
ampakine
Ampakines, also stylized as AMPAkines, are a subgroup of AMPA receptor positive allosteric modulators with a benzamide or closely related chemical structure. They are also known as "CX compounds". Ampakines take their name from the AMPA recepto ...
originally developed by
Cortex Pharmaceuticals and then licensed to
Organon International for development. In animal studies it has been shown to effectively potentiate
AMPA receptor
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic receptor, ionotropic transmembrane receptor for glutamate (iGluR) that mediates fast synapse, synap ...
function, leading to increased
BDNF release and enhanced neuronal differentiation and survival, as well as producing
nootropic effects in standardised assays. Development as an antidepressant has been halted due to a failed Phase II trial for
major depressive disorder.
See also
*
AMPA receptor positive allosteric modulator
AMPA receptor positive allosteric modulators are positive allosteric modulators (PAMs) of the receptor (AMPR), a type of ionotropic glutamate receptor which mediates most fast synaptic neurotransmission in the central nervous system.
Medical ...
References
Ampakines
AMPA receptor positive allosteric modulators
Experimental drugs
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