Occupational hazards associated with exposure to human nail dust

The use of podiatry drills, in the absence of engineering controls and personal protective equipment, is an occupational hazard to the healthcare provider. Nail dust collected during foot care procedures performed in office settings has been found to contain keratin, keratin hydrolysates, microbial debris, and viable fungal elements, including dermatophytes (most commonly '' Trichophyton rubrum'') and saprotrophs.Ward GW, Karlsson G, Rose G, Platts-Mills TAE (1989). "Trichophyton asthma: sensitization of bronchi and upper airways to dermatophytes antigen". ''Lancet'' 8643, 859-62Abramson C (1990). "Inhalation of nail dust: A podiatric hazard". In McCarthy DJ, Abramson C, Rupp MJ (eds). ''Infectious Diseases of the Lower Extremities''. Williams & Wilkins, Baltimore 293-298 Exposure to nail dust and the associated risk will vary with the policies and practices in place, the type of podiatry drill used, therapy technique, frequency of procedures, personal protective equipment utilized and the use of ventilation systems.

Nail dust generation

Healthcare providers may use podiatry drills on onychauxic (thickened) nails of patients to alleviate or eliminate pain, prevent or treat subungual ulcerations, allow better penetration of topical antifungal agents, or improve cosmesis, all in effort to improve the patient's “quality of life.”Woodfolk JA (2005). "Allergy and Dermatophytes". ''Asthma and Allergic Diseases Center, Clinical Microbiology Reviews'' 18 30-43McLarnon NA, Burrow JG, Price P, Aidoo KE, MacLaren W, Harper M, Hepher M, Edwards G (2005). "The controls of airborne hazardous substance in the healthcare environment", IOHA Pilannesberg: paper E1-1, 1-6 In a study conducted by Miller, 65% of respondents reported routinely drilling thickened toenails.Gatley M (1991). "Human nail dust: hazard to chiropodists or merely nuisance?" ''J. Soc. Occup. Med'' 41 (3) 121-5 However, the improved effectiveness of antifungal drugs such as itraconazole and terbinafine reduces the need to drill these infected nails.Sehgal VN, Jain S (2000). "Onychomycosis: clinical perspective". ''International Journal of Dermatology'' 39241-249

Podiatry drills have a mechanical rotating burr that can be set at a range of speeds usually up to 12,000 rpm and may or may not have an integrated local ventilation extraction system.http://www.podiatrytoday.com/article/775 7/5/07 Even with the most effective dust extractors, the electric nail debridement process is not totally risk free because the extractors range from 25% - 92% effective in reducing airborne particles.Abramson C and Wilton J (1985). "Inhalation of nail dust aerosols during reduction of onychomycotic toenails: I. Characterization of nail dust particles". ''JAPMA'' 75563 111-115Harvey CK (1993). "Comparison of the effectiveness of nail dust extractors". ''Journal of American Podiatric Medical Association'' 833. 12 669-673 While the large particles settle out to the floor, varying amounts of smaller particles remain suspended and are inhaled by or adhere to the practitioner and clinical environment. The particle sizes range from 0.1 to 100 um and 86% of these particles are less than 5 um in diameter and therefore capable of entry into the alveoli.

Health implications

Fungi are ubiquitous organisms that play a vital role in decomposing organic matter. Many species of fungi live on the human body and some will infect nails causing a condition called onychomycosis. There are oral and topical antifungal therapies for this condition, however, in some instances cutting, filing, or abrading the nail may be necessary to improve cure rates.(2003) "Adverse Human Health Effects Associated with Molds in the Indoor Environment". ''Journal of Occupational and Environmental Medicine'' 45(5) 470-478 Thickened nails caused by injury, infection, diabetes, psoriasis, or vascular disease may require the use of a mechanical therapy, which can expose the healthcare worker to microbial dust.

Exposure to nail dust was first discussed and described in the literature as an occupational hazard in the early 70's.Pugh J, Skone JF (1972) "The health of the chiropodist in a developing community service". ''The Chiropodist'' 27(2)53-55
In 1975, two female chiropodists were diagnosed with allergic hypersensitivity to nail dust.Davies RR, Ganderton MA (1975) "Allergic hazards in chiropody". ''Chiropodist'' 30(89) 89-92 Since that time, there have been a number of occupational-related complaints pertaining to airborne nail dust exposure and efforts have been made to study the podiatric professionals to determine related symptoms. Biological dust from the hand and foot care procedures may deposit in the conjunctiva, nose, and throughout the respiratory tract. The local irritation of these areas can lead to conjunctivitis, itching, tearing, rhinitis, sneezing, asthmatic attacks, bronchitis, and coughing.Duell B L, Arruda LK, Chapman MD, Platts-Mills TAE (1991). "''Trichophyton tonsurans'' Allergen. Characterization of a protein that causes immediate but not delayed hypersensitivity". ''Journal of Immunology'' 147 136, 96-101

The literature suggests that nail dust can be a respiratory sensitizer, which is defined as a substance that when breathed in can trigger an irreversible allergic reaction in the respiratory system.(1991) ''Medical aspects of occupational asthma''. Health and Safety Executive Publications, Medical Series 25 16 Sensitization does not usually take place immediately, but rather after months or years of exposure to the agent. Once sensitized, even the smallest amount of the substance can trigger asthma, rhinitis, or conjunctivitis that may exhibit the following symptoms: coughing, wheezing, chest tightness, runny or stuffy nose, and watery or prickly eyes. Millar found that within the podiatry profession there is four times the national prevalence of asthma.Millar NA (2000). ''The ocular risks of human nail dust in podiatry''. PhD Thesis, Glasgow Caledonian University Hypersensitivity reactions are the most probable disposition for healthcare workers inhaling nail dust, although more serious lung pathology can not be ruled out Davies RR, Ganderton MA, Savage M (1983). "Human nail dust and precipitating antibodies to ''Trichophyton rubrum'' in chiropodists". Clin Allergy 13309-315Ward PE (1995). "Atopy and reaction to nail dust inhalation". ''Clinics in Podiatric Medicine'' 12(2) 275-278

It is widely known and accepted that fungi will induce asthma, but it is estimated that only 10% of the population has allergic antibodies to fungal antigens, and half of them, that is 5% of the population, would be asymptomatic, further complicating the link between the fungal dust and troubling symptoms.Millar NA, Burrow, JG, Hay J, Stevenson R (1996) "Putative risks of ocular infection for chiropodists and podiatrists". ''Journal of British Podiatric Medicine'' 51(11) 158-160 ''Trichophyton rubrum'' is the most common fungal cause of nail dystrophy. Studies conducted in England found that the prevalence of ''trichophyton rubrum'' antibodies in podiatrists ranged from 14%-31%.Abramson, Carl and Wilton, James (1992). "Nail dust aerosols from onychomycotic toenails". ''Journal of the American Podiatric Medical Association'' 82(2)563-567 This is evidence that the podiatrist is heavily exposed to ''trichophyton rubrum'' as observed in increased precipitating antibodies compared to the general population. It has been suggested that absorption of ''trichophyton'' fungal antigens can give rise to immunoglobulin E (IgE) antibody production, sensitization of the airways, and symptomatic asthma and rhinitis.Kivity S, Schawarz Y, Fireman E (1992). "The association of perennial rhinitis with ''trichophyton infection''". ''Clinical and Experimental Allergy'' 22(4)498-500

Nail work requiring clipping and drilling is also a potential cause for ocular injury and infection to the podiatrists, podiatric staff, and patients that are exposed to nail fragments and high-speed drills used for grinding.Davis JM, Kugler G, Nixon BP (1991). "Eye Injury in a Podiatrist". ''Journal of the American Podiatric Medical Association'' 81(12)661-663 Possible ocular hazards result from exposure to foreign bodies, allergens, bacteria, viruses, fungi and protozoa that can be introduced at the time of eye trauma, or enter as a consequence of damage to the ocular structures; permitting the entry of opportunistic infection. The high-speed rotation of podiatry drill burrs potentially expose the healthcare worker to aerosols containing bloodborne pathogens such as Hepatitis B, Hepatitis C, or HIV.Bell KM, Clement DA (1991). "Eye protection for the surgeon". ''JR Coll Surg Edinb'' 36178-179 Davies et al. surveyed podiatrists and found that 41% of them complained of eye problems, particularly soreness, burning, itching and excess lacrimation.

A 1990 case illustrates the potential for ocular trauma to the healthcare provider: A podiatrist suffered a lacerated cornea when hit by a metallic shard from the grinding bit or by a fragment from the patient's toenail. The podiatrist reported fleeting periods of blurriness for several months following the incident. The healthcare worker's exposure to foreign bodies is not well documented in the literature like they are with dental staff using similar equipment; however, many of these incidents are certain to go unreported. The healthcare provider's risk of injury during nail care, however slight, warrants the use of simple and inexpensive preventative measures.

Infections in the patients

There have been numerous accounts of patients with ''trichophyton'' fungal infections and associated asthma, which further substantiates the likelihood of respiratory disease transmission to the healthcare provider being exposed to the microbe-laden nail dust.Ward GW, Woodfolk JA, Hayden ML, Jackson S, Platts-Mills TAE (1999). "Treatment of late-onset asthma with fluconazole". ''J Allergy Clin Immunol'' 104 546-550 In 1975, a dermatophyte fungal infection was described in a patient with severe tinea. The resulting treatment for mycosis improved the patient's asthmatic condition.Wise F, Sulzberger MB (1930) "Urticaria and hay fever due to Trichophyton". ''JAMA'' 95 1504 The antifungal treatment of many other ''trichophyton'' foot infections has alleviated symptoms of hypersensitivity, asthma, and rhinitis.Schwartz HJ, Ward GW (1995). "Onychomycosis, ''trichophyton'' allergy and asthma – a causal relationship?" Ann Allergy Asthma Immunol 74 523-524Platts-Mills TAE, Fiocco GP, Pollart SM, Hayden ML, Jackson S, Wilkens SR (1986). "''Trichophyton'' allergy in a 24-year-old man with intrinsic asthma". ''Ann Allergy'' 56 40-45Platts-Mills TAE, Call RS, Deuell BA, Kalsson G, Ward GW (1992). "The association of hypersensitivity diseases with dermatophytes infections". ''Clin Exp Allergy'' 22427-428Kivity S, Schwarz Y, Fireman E. (1999). "The association of perennial rhinitis with ''trichophyton'' infection". ''Clin Exp Allergy'' 22498-500

Control measures

Chronic exposure to human nail dust is a serious occupational hazard that can be minimized by not producing such dust. Best practice is to avoid electrical debridement or burring of mycotic nails unless the treatment is necessary. When the procedure is necessary, it is possible to reduce exposure by using nail dust extractors, local exhaust, good housekeeping techniques, personal protective equipment such as gloves, glasses or goggles, face shields, and an appropriately fitted disposable respirators to protect against the hazards of nail dust and flying debris.

See also

*Nail disease
*Allergy
*Hypersensitivity
*Occupational asthma

References

Industrial hygiene
Occupational diseases
Nails (anatomy)
Dust
Occupational hazards