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NM_001199770
NM_014562

NM_011023

RefSeq (protein)

NP_001186699
NP_055377

NP_035153

Location (UCSC) Chr 2: 63.05 – 63.06 Mb Chr 11: 21.99 – 22 Mb PubMed search [3] [4] Wikidata
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Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.[5][6]

Function

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. The Otx gene is active in the region of the first gill arch, which is related to the upper and lower jaw and two of the bones of the ear.[7] A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115507 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005917 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (July 1994). "Chromosome locations of human EMX and OTX genes". Genomics. 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790. 
  6. ^ a b "Entrez Gene: OTX1 orthodenticle homeobox 1". 
  7. ^ Shubin, Neil "Your Inner Fish" 2009

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.