ORG-20599 is a synthetic
neuroactive steroid, with
sedative effects resulting from its action as a
GABAA receptor
positive allosteric modulator
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs. The site that an allosteric modulator binds to ...
and, at higher concentrations,
agonist. It was developed for use as an
anaesthetic agent but was never marketed for this purpose, although it is still used in scientific research.
[Weir CJ, Ling AT, Belelli D, Wildsmith JA, Peters JA, Lambert JJ. The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. ''British Journal of Anaesthesia''. 2004 May;92(5):704-11. ]
Chemistry
References
5β-Pregnanes
Neurosteroids
Anticonvulsants
Hypnotics
4-Morpholinyl compunds
Organochlorides
Secondary alcohols
Ketones
GABAA receptor agonists
GABAA receptor positive allosteric modulators
Glycine receptor agonists
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