Nuclear factor I
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Nuclear factor I (NF-I) is a family of closely related
transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription (genetics), transcription of genetics, genetic information from DNA to messenger RNA, by binding t ...
s. They constitutively bind as dimers to specific sequences of DNA with high affinity. Family members contain an unusual DNA binding domain that binds to the
recognition sequence A recognition sequence is a DNA sequence to which a structural motif of a DNA-binding domain exhibits binding specificity. Recognition sequences are palindromes. The transcription factor Sp1 for example, binds the sequences 5'-(G/T)GGGCGG(G/A)( ...
5'-TTGGCXXXXXGCCAA- 3'. Subtypes include: * NFIA * NFIB * NFIC * NFIX


References

{{Transcription factors, g1 Transcription factors