Nuclear factor I (NF-I) is a family of closely related
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...
s. They constitutively bind as dimers to specific sequences of DNA with high affinity.
Family members contain an unusual
DNA binding domain
A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence (a recognition sequence) or have a genera ...
that binds to the
recognition sequence
A recognition sequence is a DNA sequence to which a structural motif of a DNA-binding domain exhibits binding specificity. Recognition sequences are palindromes.
The transcription factor Sp1 for example, binds the sequences 5'-(G/T)GGGCGG(G/A)(G/ ...
5'-TTGGCXXXXXGCCAA-
3'.
Subtypes include:
*
NFIA
Nuclear factor 1 A-type is a protein that in humans is encoded by the ''NFIA'' gene.
Function
Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity ...
*
NFIB
*
NFIC
*
NFIX
Nuclear factor 1 X-type is a protein that in humans is encoded by the ''NFIX'' gene. NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.
Interactions
Nfix has been shown to interact with SKI p ...
References
{{Transcription factors, g1
Transcription factors