Corbadrine (
INN; marketed as Neo-Cobefrine), also known as levonordefrin (
USAN) and α-methylnorepinephrine, is a
catecholamine sympathomimetic
Sympathomimetic drugs (also known as adrenergic drugs and adrenergic amines) are stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system. Examples of sympathomimetic effects include increases in hea ...
used as a
topical nasal
Nasal is an adjective referring to the nose, part of human or animal anatomy. It may also be shorthand for the following uses in combination:
* With reference to the human nose:
** Nasal administration, a method of pharmaceutical drug delivery
** ...
decongestant and
vasoconstrictor in
dentistry
Dentistry, also known as dental medicine and oral medicine, is the branch of medicine focused on the teeth, gums, and mouth. It consists of the study, diagnosis, prevention, management, and treatment of diseases, disorders, and conditions o ...
in the
United States,
(usually in a pre-mixed solution with
local anesthetics, such as
mepivacaine
Mepivacaine is a local anesthetic of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine) and is marketed under various trade names including C ...
).
Corbadrine is also a
metabolite
In biochemistry, a metabolite is an intermediate or end product of metabolism.
The term is usually used for small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, c ...
of the
antihypertensive drug methyldopa,
and plays a role in its
pharmacology
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
and effects.
See also
*
α-Methyldopamine
*
α-Methyltyramine
4-Hydroxyamphetamine (4HA), also known as hydroxyamfetamine, hydroxyamphetamine, oxamphetamine, norpholedrine, ''para''-hydroxyamphetamine, and α-methyltyramine, is a drug that stimulates the sympathetic nervous system.
It is used medically ...
References
External links
*
Alpha-1 adrenergic receptor agonists
Alpha-2 adrenergic receptor agonists
Beta-adrenergic agonists
Catecholamines
Norepinephrine releasing agents
Phenylethanolamines
Substituted amphetamines
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