Nitromifene (; also as the
citrate salt
Salt is a mineral composed primarily of sodium chloride (NaCl), a chemical compound belonging to the larger class of salts; salt in the form of a natural crystalline mineral is known as rock salt or halite. Salt is present in vast quantitie ...
nitromifene citrate (), developmental code names CI-628, CN-5518, CN-55945) is a
nonsteroidal selective estrogen receptor modulator
Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonist/antagonists (ERAAs), are a class of drugs that act on the estrogen receptor (ER). A characteristic that distinguishes these substances from pure ER agonists a ...
(SERM) related to
triphenylethylenes like
tamoxifen
Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and treat breast cancer in women and men. It is also being studied for other types of cancer. It has b ...
that was never marketed.
It is a mixture of (''E'')- and (''Z'')-
isomer
In chemistry, isomers are molecules or polyatomic ions with identical molecular formulae – that is, same number of atoms of each element – but distinct arrangements of atoms in space. Isomerism is existence or possibility of isomers.
Iso ...
s that possess similar
antiestrogenic activity.
The drug was described in 1966.
Along with tamoxifen,
nafoxidine
Nafoxidine (; developmental code names U-11,000A) or nafoxidine hydrochloride () is a nonsteroidal selective estrogen receptor modulator (SERM) or partial antiestrogen of the triphenylethylene group that was developed for the treatment of adv ...
, and
clomifene, it was one of the earliest SERMs.
Nitromifene has been found to dissociate from the
estrogen receptor 250-fold faster than
estradiol.
This may be involved in its antagonistic activity at the estrogen receptor.
References
Abandoned drugs
Nitro compounds
Pyrrolidines
Selective estrogen receptor modulators
{{Genito-urinary-drug-stub