Neuropeptide Y receptor type 2 (Y2R) is a member of the
neuropeptide Y receptor
Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are invo ...
family of
G-protein coupled receptors, that in humans is encoded by the ''NPY2R''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Selective ligands
Agonists
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Neuropeptide Y
Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. NPY has been identified as the most abundant peptide present in the ma ...
(endogenous agonist, non subtype selective)
* Neuropeptide Y fragment 13-36 (NPY
2 selective agonist)
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Peptide YY
* Peptide YY 3-36 fragment
Antagonists
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BIIE-0246
BIIE-0246 is a drug used in scientific research which acts as a potent and selective antagonist for the Neuropeptide Y receptor Y2. It was one of the first non-peptide Y2-selective antagonists developed, and remains among the most widely used to ...
(CAS# 246146-55-4)
* JNJ 5207787 (CAS# 683746-68-1)
* SF 11 (CAS# 443292-81-7)
See also
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Neuropeptide Y receptor
Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are invo ...
References
External links
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Further reading
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G protein-coupled receptors
{{transmembranereceptor-stub