The neuromedin U receptors are two

G-protein coupled receptor G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...

s which bind the neuropeptide hormones neuromedin U and neuromedin S. There are two subtypes of the neuromedin U receptor, each encoded by a separate gene (, ).

Selective Ligands

Neuromedin U is an agonist at both the NMU₁ and NMU₂ subtypes, while neuromedin S is selective for NMU₂, and is a more potent agonist at this subtype than neuromedin U. Several other peptide and non-peptide ligands are also available for the NMU receptors.

Agonists

;Non-selective * Neuromedin U * non-peptide NMU modulators Kajino M, Hinuma S, Tarui N, Yamashita T, Nakayama Y. Receptor regulators. European Patent EP 1559428 A1. Published 03.08.2005 ;NMU₂ selective * Neuromedin S

Selective Ligands

Agonists

Antagonists

References

External links