Nancy Kleckner is the Herchel Smith Professor of Molecular Biology at

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of high ...

and principal investigator at the Kleckner Laboratory at

Education

Nancy Kleckner worked with Matt Meselson as an undergraduate at

, earning her degree in 1968. She then moved on to do her PhD at

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...

working with Ethan Signer on the genetics of

lambda phage ''Enterobacteria phage λ'' (lambda phage, coliphage λ, officially ''Escherichia virus Lambda'') is a bacterial virus, or bacteriophage, that infects the bacterial species ''Escherichia coli'' (''E. coli''). It was discovered by Esther Leder ...

and

DNA replication In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. DNA replication occurs in all living organisms acting as the most essential part for biological inheritanc ...

. She did a postdoc under

David Botstein David Botstein (born September 8, 1942) is an American biologist serving as the chief scientific officer of Calico. He served as the director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University from 2003 to 2013, where ...

Princeton University Princeton University is a private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth as the College of New Jersey, Princeton is the fourth-oldest institution of higher education in the United States and one of the ...

in 1974.

Career

Kleckner returned to Harvard as a professor in 1977 and was awarded tenure in 1985. Her first graduate student at Harvard was

Victoria Lundblad Victoria Lundblad is an American geneticist whose work focuses on the genetic control of chromosome behavior in yeast. Many of her discoveries have concerned telomerase, the RNA-containing enzyme that completes the ends of chromosomes. She works a ...

, who discovered the gene-enzyme systems of yeast that control formation of

telomeres A telomere (; ) is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes. Although there are different architectures, telomeres, in a broad sense, are a widespread genetic feature mos ...

. Her work in

transposons A transposable element (TE, transposon, or jumping gene) is a nucleic acid sequence in DNA that can change its position within a genome, sometimes creating or reversing mutations and altering the cell's genetic identity and genome size. Tran ...

and

mutagenesis Mutagenesis () is a process by which the genetic information of an organism is changed by the production of a mutation. It may occur spontaneously in nature, or as a result of exposure to mutagens. It can also be achieved experimentally using lab ...

has been largely productive, and led her to study the physical mechanism of chromosome replication. She discovered SeqA, a protein involved in initiation of DNA replication. Currently, she runs the Kleckner Lab at Harvard University which performs research related to

chromosome A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are ...

and membrane mechanics.

Awards

* 1990 Genetics Society of America Medal * 1993 Elected to the National Academy of Sciences * 2016

Thomas Hunt Morgan Medal The Thomas Hunt Morgan Medal is awarded by the Genetics Society of America (GSA) for lifetime contributions to the field of genetics. The medal is named after Thomas Hunt Morgan, the 1933 Nobel Prize winner, who received this award for his work wi ...

for lifetime achievement in the field of genetics * Elected Fellow of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...

* Elected Fellow of the

American Association for the Advancement of Sciences The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsi ...

* Elected Fellow of the

American Academy of Microbiology The American Society for Microbiology (ASM), originally the Society of American Bacteriologists, is a professional organization for scientists who study viruses, bacteria, fungi, algae, and protozoa as well as other aspects of microbiology. It wa ...

References

Year of birth missing (living people) Living people Harvard University faculty American molecular biologists Harvard University alumni Massachusetts Institute of Technology alumni Members of the United States National Academy of Sciences {{US-biologist-stub