Naltriben is a potent and selective
antagonist for the
delta opioid receptor
Delta commonly refers to:
* Delta (letter) (Δ or δ), a letter of the Greek alphabet
* River delta, at a river mouth
* D (NATO phonetic alphabet: "Delta")
* Delta Air Lines, US
* Delta variant of SARS-CoV-2 that causes COVID-19
Delta may also r ...
, which is used in scientific research. It has similar effects to the more widely used δ antagonist
naltrindole
Naltrindole is a highly potent, highly selective delta opioid receptor antagonist used in biomedical research. In May 2012 a paper was published in ''Nature'' with the structure of naltrindole in complex with the mouse δ-opioid G-protein coupled ...
, but with different binding affinity for the δ
1 and δ
2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors. It also acts as a
κ-opioid agonist at high doses.
See also
*
Nalfurafine
Nalfurafine (International Nonproprietary Name, INN, United States Adopted Name, USAN) (brand name Remitch; former developmental code names TRK-820, AC-820, MT-9938) is an antipruritic (anti-itch drug) that is marketed in Japan for the treatment ...
*
Nalmefene
Nalmefene is an opioid antagonist medication used in the management of opioid overdose and alcohol dependence. It is taken by mouth.
Nalmefene is an opiate derivative similar in both structure and activity to the opioid antagonist naltrexone. ...
*
Naltrindole
Naltrindole is a highly potent, highly selective delta opioid receptor antagonist used in biomedical research. In May 2012 a paper was published in ''Nature'' with the structure of naltrindole in complex with the mouse δ-opioid G-protein coupled ...
References
{{Opioidergics
Delta-opioid receptor antagonists
Dibenzofurans
4,5-Epoxymorphinans
Phenols
Tertiary alcohols
Kappa-opioid receptor agonists
Semisynthetic opioids