Naloxonazine is a potent,
irreversible μ-opioid receptor
The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins. They are also referred to as μ(''mu'')-opioid peptide (MOP) receptors. The prototypical Π...
antagonist.
Naloxonazine dihydrochloride
/ref> Naloxonazine forms spontaneously in acidic solutions of naloxazone, and may be responsible for much or all of the irreversible μ opioid receptor binding displayed by the latter.
See also
* Oxymorphone-3-methoxynaltrexonazine, a similar opioid also having two complete and mirrored morphinan carbon skeletons
References
4,5-Epoxymorphinans
Mu-opioid receptor antagonists
Phenols
Allyl compounds
Semisynthetic opioids
Alkylating agents
Irreversible antagonists
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