Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the ''NUP153'' gene. It is an essential component of the basket of
nuclear pore complexes
A nuclear pore is a part of a large complex of proteins, known as a nuclear pore complex that spans the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are approximately 1,000 nuclear pore complexes ...
(NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin.
On the cytoplasmic side of the NPC,
Nup358
RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the ''RANBP2'' gene. It is also known as nucleoporin 358 (Nup358) since it is a member nucleoporin family that makes up the nuclear pore complex. RanBP2 has a mass of 358 kDa.
...
fulfills an analogous role.
Background
Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are pore complex-specific glycoproteins characterized by cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG.
Structure
Nucleoporin 153 has a mass of 153 kDA (hence its name). It is filamentous and it contains three distinct domains: a N-terminal region within which a pore targeting domain has been identified, a central region containing multiple
zinc finger
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. It was originally coined to describe the finger-like appearance of a hypothesized struct ...
motifs, and a C-terminal region containing multiple XFXFG repeats.
Interactions
NUP153 has been shown to
interact
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with
SENP2
Sentrin-specific protease 2 is an enzyme that in humans is encoded by the ''SENP2'' gene.
Function
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of protea ...
and
KPNB1
Importin subunit beta-1 is a protein that in humans is encoded by the ''KPNB1'' gene.
Function
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. ...
.
References
Further reading
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{{Autoantigens
Nuclear pore complex