NRL (gene)

Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the ''NRL'' gene.

Function

This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoreceptor cell development and function. Mutations in this gene have been associated with retinitis pigmentosa and degenerative diseases of the retina.

See also

* Transcription factor

References

Further reading

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External links

GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview
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Transcription factors

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