RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a
nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroid hormone, steroids, thyroid hormone, thyroid hormones, vitamins, and certain other molecules. These receptors work with other proteins to ...
that in humans is encoded by the ''RORB'' gene.
Function
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to
hormone response element Response elements are short sequences of DNA within a gene promoter or enhancer region that are able to bind specific transcription factors and regulate transcription of genes.
Under conditions of stress, a transcription activator protein bin ...
s upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with
NM23-2, a
nucleoside-diphosphate kinase
Nucleoside-diphosphate kinases (NDPKs, also NDP kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes that catalyze the exchange of terminal phosphate between different nucleoside diphosphates (NDP) and triphosphates (NTP) ...
involved in organogenesis and differentiation.
In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.
A mutation in this gene also results in the loss of spinal cord interneurons and of saltatorial locomotion,
a type of hopping gait that in mammals can be found in rabbits, hares, kangaroos, and some species of rodents.
Interactions
RAR-related orphan receptor beta has been shown to
interact
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with
NME1.
See also
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RAR-related orphan receptor
References
Further reading
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External links
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Intracellular receptors
Transcription factors
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