RefSeq (protein)



Location (UCSC) Chr 7: 144.4 – 144.41 Mb Chr 6: 43.3 – 43.31 Mb PubMed search [3] [4] Wikidata
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Homeobox protein NOBOX, also known as newborn ovary homeobox protein, is a protein that in humans is encoded by the NOBOX gene.[5][6][7]


NOBOX is a homeobox gene that is preferentially expressed in oocytes. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes.[7]

Clinical significance

A mutation in the NOBOX gene is associated with premature ovarian failure.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106410 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029736 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: NOBOX oogenesis homeobox". 
  6. ^ Suzumori N, Yan C, Matzuk MM, Rajkovic A (Feb 2002). "Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes". Mechanisms of Development. 111 (1-2): 137–41. doi:10.1016/S0925-4773(01)00620-7. PMID 11804785. 
  7. ^ a b Huntriss J, Hinkins M, Picton HM (May 2006). "cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles". Molecular Human Reproduction. 12 (5): 283–9. doi:10.1093/molehr/gal035. PMID 16597639. 
  8. ^ Qin Y, Choi Y, Zhao H, Simpson JL, Chen ZJ, Rajkovic A (Sep 2007). "NOBOX homeobox mutation causes premature ovarian failure". American Journal of Human Genetics. 81 (3): 576–81. doi:10.1086/519496. PMC 1950834Freely accessible. PMID 17701902. 

Further reading