The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''NCOR1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
NCOR1 is a transcriptional coregulatory protein which contains several
nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These receptors work with other proteins to regulate the expression of speci ...
interacting domains. In addition, NCOR1 appears to recruit
histone deacetylase
Histone deacetylases (, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around his ...
s to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of gene expression.
Loss of function of this protein significantly increases the strength and power of mouse muscles.
Family
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is
Nuclear receptor co-repressor 2
The nuclear receptor co-repressor 2 () is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists ...
.
[UniPro]
Nuclear receptor corepressors family
Page accessed June 26, 2016
Interactions
Nuclear receptor co-repressor 1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
Androgen receptor
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in th ...
,
*
CHD1
The Chromodomain-Helicase DNA-binding 1 is a protein that, in humans, is encoded by the CHD1 gene. CHD1 is a chromatin remodeling protein that is widely conserved across many eukaryotic organisms, from yeast to humans. CHD1 is named for three of i ...
,
*
Calcitriol receptor
*
GPS2,
[
* Glucocorticoid receptor,]HDAC3
Histone deacetylase 3 is an enzyme encoded by the ''HDAC3'' gene in both humans and mice.
Function
Histones are highly alkaline proteins that package and order DNA into structural units called nucleosomes, which comprise the major protein comp ...
,[
* ]HDAC7A
Histone deacetylase 7 is an enzyme that in humans is encoded by the ''HDAC7'' gene.
Function
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters ...
,HDAC9
Histone deacetylase 9 is an enzyme that in humans is encoded by the ''HDAC9'' gene.
Function
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters ...
,HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) also known as cardiovascular helix-loop-helix factor 1 (CHF1) is a protein that in humans is encoded by the ''HEY2'' gene.
This protein is a type of transcription factor that belong ...
,MECP2
''MECP2'' (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. MECP2 appears to be essential for the normal function of nerve cells. The protein seems to be particularly important for mature nerve cells, where it is present in ...
,Promyelocytic leukemia protein
Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bod ...
,RUNX1T1
Protein CBFA2T1 is a protein that in humans is encoded by the ''RUNX1T1'' gene.
Function
The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, ...
,Retinoic acid receptor gamma
Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the ''RARG'' gene. Adapalene selectively targets retinoic acid receptor beta and retinoic acid receptor ...
,[
* SAP30,]TBL1XR1
F-box-like/WD repeat-containing protein TBL1XR1 is a protein that in humans is encoded by the ''TBL1XR1'' gene. The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a ...
,TBL1X
Transducin (beta)-like 1X-linked, also known as TBL1X, is a protein which in humans is encoded by the ''TBL1X'' gene.
Function
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. ...
,ZBTB33
Transcriptional regulator Kaiso is a protein that in humans is encoded by the ''ZBTB33'' gene. This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consen ...
.[
]
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
External links
*
*
*
{{Transcription coregulators
Transcription coregulators