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Monatepil is a calcium channel blocker and α1-adrenergic receptor antagonist used as an
Acylation of 745-53-5(1) with 4-chlorobutyryl chloride 635-59-0(2) then leads to the corresponding amide 4-Chloro-N-(5,11-dihydro-10-thia-dibenzo ,dyclohepten-5-yl)-butyramide 03379-37-9(3). Alkylation with para-Fluorophenylpiperazine 252-63-3(4) then completed the synthesis of monatepil (5).
antihypertensive
Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests tha ...
.Synthesis
Acylation of 745-53-5(1) with 4-chlorobutyryl chloride 635-59-0(2) then leads to the corresponding amide 4-Chloro-N-(5,11-dihydro-10-thia-dibenzo ,dyclohepten-5-yl)-butyramide 03379-37-9(3). Alkylation with para-Fluorophenylpiperazine 252-63-3(4) then completed the synthesis of monatepil (5).
References
Alpha-1 blockers Calcium channel blockers Carboxamides Dibenzothiepines Fluoroarenes Phenylpiperazines {{Cardiovascular-drug-stub