Michael M. Gottesman (born October 7, 1946, in Jersey City, New JerseyBiography
as a speaker at the 1999 Conference on Biologic and Molecular Mechanisms for Sex Differences in Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics, Office of Research on Women's Health, retrieved 2010-02-28.) is an American biochemist and

physician-scientist A physician-scientist is traditionally a holder of a medical degree and a doctor of philosophy also known as an MD-PhD. Compared to other clinicians, physician-scientists invest significant time and professional effort in scientific research an ...

. He was the deputy director (Intramural) of the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

(NIH) in the United States, and also Chief of the Laboratory of Cell Biology at the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...

(NCI) within the NIH. He graduated summa cum laude in biochemical sciences in 1966 from Harvard College, and received his M.D. magna cum laude from

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

in 1970. He then worked as an intern and resident at the Peter Dent Brigham Hospital in

Boston Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- mo ...

, a research associate at the NIH, and an assistant professor at Harvard before taking a permanent position at the NIH in 1976. His areas of expertise includes a major contribution to the discovery of P-glycoprotein (MDR1, ABCB1), the

multidrug resistance Multiple drug resistance (MDR), multidrug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to at least one antimicrobial drug in three or more antimicrobial categories. Antimicrobial categories are c ...

efflux transporter associated with clinical resistance to anti-cancer agents. In 2007, he reported for the first time in

Science magazine ''Science'', also widely referred to as ''Science Magazine'', is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, ...

that silent polymorphisms can impact on the

tertiary structure Protein tertiary structure is the three dimensional shape of a protein. The tertiary structure will have a single polypeptide chain "backbone" with one or more protein secondary structures, the protein domains. Amino acid side chains may i ...

and function of a protein. Gottesman is an elected member of the American Association for the Advancement of Science (1988), the

National Academy of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Eng ...

(2003), the

Association of American Physicians The Association of American Physicians (AAP) is an honorary medical society founded in 1885 by the Canadian physician Sir William Osler and six other distinguished physicians of his era for "the advancement of scientific and practical medicine." ...

(2006), the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...

(2010), and the National Academy of Sciences (2018). On August 1, 2022, Gottesman was succeeded as director of the

NIH Intramural Research Program The NIH Intramural Research Program (IRP) is the internal research program of the National Institutes of Health (NIH), known for its synergistic approach to biomedical science. With 1,200 Principal Investigators and over 4,000 Postdoctoral Fellow ...

by pediatric neurologist Nina F. Schor.

References

External links

NIH Intramural Research Program websiteNIH homepageNIH Institutes, Centers and Offices
1946 births Living people Harvard Medical School alumni 20th-century American biochemists Fellows of the American Association for the Advancement of Science Fellows of the American Society for Pharmacology and Experimental Therapeutics Members of the National Academy of Medicine Physician-scientists American medical researchers 21st-century American biochemists 20th-century American physicians 21st-century American physicians National Institutes of Health people Harvard College alumni {{US-gov-bio-stub